[突尼斯的单克隆丙种球蛋白病]

[Monoclonal gammopathies in Tunisia].

作者信息

Makni S, Zouari R, Barbouch M R, Ayed K, Moalla M, Zakraoui L

机构信息

Laboratoire d'immunologie, Hôpital Charles Nicolle, Tunis.

出版信息

Rev Fr Transfus Hemobiol. 1990 Jan;33(1):31-8. doi: 10.1016/s1140-4639(05)80003-6.

DOI:10.1016/s1140-4639(05)80003-6

PMID:2187443

Abstract

Protein electrophoresis and immunoelectrophoresis carried out on 4805 sera and 93 urine samples from Tunisian patients over 8 years, and a monoclonal protein was detected in 198 cases. The distribution of the monoclonal compounds to the clinical diagnosis was studied. 115 (58%) were classified as multiple myeloma (MK), 34 (17%) as alpha heavy chain disease (MCL a), 34 (17%) as monoclonal gammapathy associated to various diseases (GMOD), 11 (6%) as benign essential monoclonal gammapathies (GMBE), 4 (2%) as Waldenström's macroglobulinemia (MW). The relationship between the monoclonal immunoglobulin and the clinical diagnosis, the distribution of the monoclonal compounds according to the heavy chain class and the identification of the light chains were studied. The results obtained are in line with the principal data in literature concerning monoclonal gammapathy. However there is a particularity about monoclonal gammapathy observed in the Tunisian's population studied: Higher percentage of alpha heavy chain diseases, monoclonal IgD and monoclonal light chain. Lower percentage of monoclonal IgM in GMBE or GMOD, as in MW.

摘要

在8年时间里，对突尼斯患者的4805份血清和93份尿液样本进行了蛋白质电泳和免疫电泳，共检测出198例单克隆蛋白。研究了单克隆化合物在临床诊断中的分布情况。115例（58%）被归类为多发性骨髓瘤（MK），34例（17%）为α重链病（MCL a），34例（17%）为与各种疾病相关的单克隆丙种球蛋白病（GMOD），11例（6%）为良性原发性单克隆丙种球蛋白病（GMBE），4例（2%）为华氏巨球蛋白血症（MW）。研究了单克隆免疫球蛋白与临床诊断之间的关系、单克隆化合物根据重链类别进行的分布以及轻链的鉴定。所获得的结果与文献中关于单克隆丙种球蛋白病的主要数据一致。然而，在所研究的突尼斯人群中观察到的单克隆丙种球蛋白病存在一个特点：α重链病、单克隆IgD和单克隆轻链的比例较高。GMBE或GMOD以及MW中，单克隆IgM的比例较低。