[Perioperative short-term preventive antibiotics in head-neck surgery].

A prospective perioperative trial with cefotiam and metronidazol was carried out in 114 patients undergoing head and neck surgery. The patients were stratified in one group receiving a single-dose prophylaxis and a second group receiving a 24-hour prophylaxis. The postoperative complication rates were analysed depending on various risk factors and the size and duration of surgery. For operations of similar size the long term prophylaxis had no advantage over the one-dose prophylaxis. It is concluded that a one-dose prophylaxis appears sufficient in major head and neck cases.