Zhou Xin
Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, 430071 Wuhan, Hubei Province, China.
Methods Mol Biol. 2011;771:189-204. doi: 10.1007/978-1-61779-219-9_10.
Hyperpolarized noble gases ((3)He and (129)Xe) can provide NMR signal enhancements of 10,000 to 100,000 times that of thermally polarized gases and have shown great potential for applications in lung magnetic resonance imaging (MRI) by greatly enhancing the sensitivity and contrast. These gases obtain a highly polarized state by employing a spin exchange optical pumping technique. In this chapter, the underlying physics of spin exchange optical pumping for production of hyperpolarized noble gases is explained and the basic components and procedures for building a polarizer are described. The storage and delivery strategies of hyperpolarized gases for in vivo imaging are discussed. Many of the problems that are likely to be encountered in practical experiments and the corresponding detailed approaches to overcome them are also discussed.
超极化惰性气体（³He和¹²⁹Xe）可使核磁共振信号增强至热极化气体的10000至100000倍，并通过大幅提高灵敏度和对比度，在肺部磁共振成像（MRI）中展现出巨大的应用潜力。这些气体通过自旋交换光泵浦技术获得高极化状态。在本章中，将解释用于产生超极化惰性气体的自旋交换光泵浦的基本物理原理，并描述构建极化器的基本组件和步骤。还将讨论用于体内成像的超极化气体的储存和输送策略。此外，还将讨论实际实验中可能遇到的许多问题以及克服这些问题的相应详细方法。
