利用分子间多量子相干的磁共振成像。
MRI using intermolecular multiple-quantum coherences.
作者信息
Branca Rosa Tamara
机构信息
Department of Chemistry, Duke University, Durham, NC 27708, USA.
出版信息
Methods Mol Biol. 2011;771:241-52. doi: 10.1007/978-1-61779-219-9_13.
Intermolecular multiple-quantum coherences (iMQCs) can generate NMR signals from exceedingly small dipolar interactions between distant spins in solutions. In the last few years, these signals have been used for a wide range of applications in imaging and high-resolution spectroscopy. Recent applications include MRI contrast enhancement, suppression of inhomogeneous broadening in NMR experiments, and more recently, in vivo temperature measurement. In this chapter, we describe how basic iMQC pulse sequences work and how to select the sequence parameters to optimize iMQC signals and to overcome signal contamination.
分子间多量子相干（iMQC）能够从溶液中远距离自旋之间极其微弱的偶极相互作用产生核磁共振信号。在过去几年中，这些信号已被广泛应用于成像和高分辨率光谱学领域。最近的应用包括磁共振成像（MRI）造影增强、核磁共振实验中不均匀展宽的抑制，以及最近的体内温度测量。在本章中，我们将描述基本的iMQC脉冲序列如何工作，以及如何选择序列参数以优化iMQC信号并克服信号污染。
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