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瑞典一例麻痹型脊髓灰质炎病例的流行病学事件

Epidemiological events surrounding a paralytic case of poliomyelitis in Sweden.

作者信息

Böttiger M, Mellin P, Romanus V, Söderström H, Wesslen T, von Zeipel G

出版信息

Bull World Health Organ. 1979;57(1):99-103.

PMID:218746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2395749/
Abstract

A case of clinical poliomyelitis occurred in Sweden in January 1977; it was the first indigenous case in Sweden since 1962. This incident was of particular interest as it provided an opportunity to study the spread of virus in a cluster of unvaccinated persons and in individuals more or less fully vaccinated with inactivated vaccine. The patient excreted wild type 2 virus and the same type was isolated from 25 other individuals, all of whom were close contacts of virus excretors. Among the close contacts, 14 of 20 unvaccinated preschool children were found to excrete virus, but excretion was not found in any of the 7 vaccinated children examined.

摘要

1977年1月瑞典出现了一例临床脊髓灰质炎病例;这是自1962年以来瑞典首例本土病例。该事件特别引人关注,因为它提供了一个机会来研究病毒在一群未接种疫苗的人群以及或多或少已完全接种灭活疫苗的个体中的传播情况。患者排出野生2型病毒,并且从其他25个人中也分离出了相同类型的病毒,所有这些人都是病毒排出者的密切接触者。在密切接触者中,20名未接种疫苗的学龄前儿童中有14名被发现排出病毒,但在接受检查的7名接种疫苗的儿童中均未发现病毒排出情况。

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本文引用的文献

1
Antigenic analysis of polioviruses by kinetic studies of serum neutralization.通过血清中和动力学研究对脊髓灰质炎病毒进行抗原分析。
Virology. 1959 Jan;7(1):45-58. doi: 10.1016/0042-6822(59)90176-x.
2
Seroimmune patterns for poliomyelitis in Sweden.瑞典脊髓灰质炎的血清免疫模式。
Arch Gesamte Virusforsch. 1957;7(2):191-205. doi: 10.1007/BF01241819.
3
Control of influenza and poliomyelitis with killed virus vaccines.使用灭活病毒疫苗控制流感和脊髓灰质炎
Science. 1977 Mar 4;195(4281):834-47. doi: 10.1126/science.320661.