Division of Pediatric Surgery, Department of Surgery, Tawam Hospital, Al-Ain, AbuDhabi, United Arab Emirates.
World J Pediatr. 2013 Feb;9(1):80-3. doi: 10.1007/s12519-011-0305-5. Epub 2011 Aug 27.
Survivors of childhood malignancies are known to be at an increased risk for developing a variety of secondary cancers. Primary adenocarcinoma of the colon is very rare in children and adenocarcinoma of the colon occurring as a secondary malignancy in children is much rarer.
A boy with a history of successfully treated embryonal rhabdomyosarcoma developed adenocarcinoma of the colon as a secondary cancer.
The boy presented with a solid mass of the left cheek at 3 years of age. The mass was excised and histological examination showed embryonal rhabdomyosarcoma. He was treated with multi-agent chemotherapy and local radiotherapy, which resulted in complete remission. Four years later, he presented with recurrent colicky abdominal pain and bleeding per rectum and was found to have intussusceptions. Colonoscopy revealed a tumor in the transverse colon, which was biopsied and proved to be an adenocarcinoma. The boy underwent excision followed by chemotherapy using an adult colon cancer regimen. He is currently off chemotherapy for 2 years with no evidence of the disease.
We report a rare case of colon cancer after treatment of rhabdomyosarcoma. Colorectal adenocarcinoma must be kept in mind as a secondary neoplasm following treatment for early childhood malignancies although it is extremely rare.
已知儿童恶性肿瘤幸存者发生多种继发性癌症的风险增加。儿童原发性结肠癌非常罕见，而儿童继发性结肠癌则更为罕见。
一名曾成功治疗胚胎性横纹肌肉瘤的男孩发生了结肠癌的继发性癌症。
这名男孩在 3 岁时出现左侧脸颊实性肿块。肿块被切除，组织学检查显示胚胎性横纹肌肉瘤。他接受了多药物化疗和局部放疗，结果完全缓解。4 年后，他出现反复发作的痉挛性腹痛和直肠出血，并发现有肠套叠。结肠镜检查显示横结肠有一个肿瘤，活检证实为腺癌。男孩接受了切除手术，随后使用成人结肠癌方案进行化疗。他目前已停止化疗 2 年，无疾病证据。
我们报告了一例横纹肌肉瘤治疗后罕见的结肠癌病例。虽然极其罕见，但结直肠腺癌必须作为儿童期恶性肿瘤治疗后的继发性肿瘤加以考虑。
