Molnar Sven, Mihanović Mate, Grah Majda, Kezić Slobodanka, Filaković Pavo, Degmecić Dunja
Sveti Ivan Psychiatric Hospital, Zagreb, Croatia.
Coll Antropol. 2010 Dec;34(4):1427-32.
Schizophrenia and suicidal behaviour are sever and complex mental disorders, largely determined by factors of inheritance. Both disorders present pathological changes in the catecholamine neurotransmitter system. The study was conducted on three groups; a group of subjects suffering from schizophrenia, a second compounded by individuals who attempted suicide and a third group of phenotypically healthy examinees. The blood samples of schizophrenic patients as of those who attempted suicide were obtained at the Psychiatric Hospital "Sveti Ivan" in Zagreb in the year 2004. Tests were conducted on the statistic relation between a total of 18 SNPs within three candidate-genes of the dopamine and adrenergic system (DRD4, SLC6A3 and ADRA2B) and the manifestation of schzophrenia and suicidal behaviour. Cases were genotyped by use of SNPlex system. Statistically significant differences were determined in the allelic frequency between the mentioned groups. Findings show a significant connection between 4 SNPs (ADRA2B rs749457, SLC6A3 rs464094, DRD4 rs11246226 and rs4331145) and schizophrenia, and 2 SNPs with suicidal attempt (ADRA2B rs1018351 i SLC6A3 rs403636). In addition, this is the first study that highlights the potential role/effect of polymorphisms in ADRA2B on the manifestation of schizophrenia, as on suicidal behaviour.
精神分裂症和自杀行为是严重且复杂的精神障碍，很大程度上由遗传因素决定。这两种障碍在儿茶酚胺神经递质系统中均呈现出病理变化。该研究针对三组人群开展：一组是精神分裂症患者，第二组是由自杀未遂者组成，第三组是表型健康的受测者。2004年，在萨格勒布的“圣伊万”精神病院采集了精神分裂症患者以及自杀未遂者的血样。对多巴胺和肾上腺素能系统的三个候选基因（DRD4、SLC6A3和ADRA2B）内总共18个单核苷酸多态性（SNP）与精神分裂症及自杀行为的表现之间的统计关系进行了测试。通过使用SNPlex系统对病例进行基因分型。在上述几组人群的等位基因频率上确定了具有统计学意义的差异。研究结果显示，4个SNP（ADRA2B rs749457、SLC6A3 rs464094、DRD4 rs11246226和rs4331145）与精神分裂症之间存在显著关联，2个SNP与自杀未遂（ADRA2B rs1018351和SLC6A3 rs403636）存在显著关联。此外，这是第一项突出显示ADRA2B基因多态性在精神分裂症表现以及自杀行为方面潜在作用/影响的研究。
