耳蜗微循环的病理生理学。
Physiopathology of the cochlear microcirculation.
机构信息
Oregon Hearing Research Center (NRC04), Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
出版信息
Hear Res. 2011 Dec;282(1-2):10-24. doi: 10.1016/j.heares.2011.08.006. Epub 2011 Aug 23.
Abstract
Normal blood supply to the cochlea is critically important for establishing the endocochlear potential and sustaining production of endolymph. Abnormal cochlear microcirculation has long been considered an etiologic factor in noise-induced hearing loss, age-related hearing loss (presbycusis), sudden hearing loss or vestibular function, and Meniere's disease. Knowledge of the mechanisms underlying the pathophysiology of cochlear microcirculation is of fundamental clinical importance. A better understanding of cochlear blood flow (CoBF) will enable more effective management of hearing disorders resulting from aberrant blood flow. This review focuses on recent discoveries and findings related to the physiopathology of the cochlear microvasculature.
摘要
正常的耳蜗血液供应对于建立内淋巴液的内淋巴液电位和维持内淋巴液的产生至关重要。耳蜗微循环异常一直被认为是噪声性听力损失、年龄相关性听力损失（老年性聋）、突发性听力损失或前庭功能障碍和梅尼埃病的病因之一。了解耳蜗微循环病理生理学的机制具有重要的临床意义。更好地理解耳蜗血流（CoBF）将能够更有效地管理由于血流异常引起的听力障碍。这篇综述重点介绍了与耳蜗微血管生理学相关的最新发现。
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