Neonatal Unit, Homerton Healthcare NHS Foundation Trust, London, UK.
Child Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
BMJ Paediatr Open. 2024 Nov 13;8(1):e002487. doi: 10.1136/bmjpo-2023-002487.
Hypoxic ischaemic encephalopathy (HIE), a condition where the brain does not receive enough oxygen and/or blood flow around the time of birth, is associated with significant morbidity and mortality. Systemic circulation may be affected due to poor myocardial function. The cochlear hair cells are vulnerable to changes in microcirculation, which may occur in HIE predisposing to hearing loss. Therefore, all infants with HIE undergo neurodevelopmental surveillance after discharge to monitor for adverse neurodevelopment including speech and hearing problems. This study will examine the incidence of confirmed hearing loss in newborn infants with any stage of HIE (cases) and compare them with controls.
All infants diagnosed with any stage of HIE (cases) over a 12-year period (January 2010 to December 2021) will be examined. Controls were newborn infants without HIE who were admitted to the neonatal unit and received intensive care including antibiotics (control group 1) and stable infants in the postnatal ward who received antibiotics (eg, gentamicin) (control group 2). Controls matched for gestation, gender and birth weight will be selected from a similar time period. Infant details and hearing screening data will be gathered from prospectively entered BadgerNet and S4H system databases, respectively. Categorical data will be analysed using the χ test. Predictors for hearing loss will be performed using binary logistic regression analysis.
The study is approved by the Health and Care Research Wales (HCRW) Research Ethics Committee and the Health Research Authority (HRA) (reference 21/HRA/4506). The study findings will be presented at national/international conferences and published in peer-reviewed scientific journals.
缺氧缺血性脑病（HIE）是一种由于出生时大脑缺氧和/或血流不足导致的疾病，与较高的发病率和死亡率相关。全身循环可能会受到心肌功能不良的影响。耳蜗毛细胞容易受到微循环变化的影响，这种变化可能在 HIE 中发生，导致听力损失。因此，所有患有 HIE 的婴儿在出院后都会进行神经发育监测，以监测包括言语和听力问题在内的不良神经发育情况。本研究将检查任何阶段 HIE（病例）新生儿确诊听力损失的发生率，并将其与对照组进行比较。
在 12 年期间（2010 年 1 月至 2021 年 12 月），将对所有被诊断为任何阶段 HIE 的婴儿（病例）进行检查。对照组为无 HIE 并入住新生儿病房接受包括抗生素在内的强化治疗的新生儿（对照组 1）和在产后病房接受抗生素（如庆大霉素）治疗的稳定婴儿（对照组 2）。将从相似时期选择与胎龄、性别和出生体重相匹配的对照组。婴儿详细信息和听力筛查数据将分别从前瞻性录入的 BadgerNet 和 S4H 系统数据库中收集。将使用 χ 检验分析分类数据。使用二项逻辑回归分析对听力损失的预测因素进行分析。
该研究已获得威尔士健康与护理研究伦理委员会（HCRW）和健康研究管理局（HRA）的批准（参考号 21/HRA/4506）。研究结果将在国内/国际会议上进行展示，并发表在同行评议的科学期刊上。
