Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
J Neuroimmunol. 2011 Oct 28;239(1-2):91-7. doi: 10.1016/j.jneuroim.2011.08.008. Epub 2011 Aug 27.
No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD.
目前在神经白塞病（NBD）中尚未定义特定于疾病的神经元抗体。免疫组化和免疫细胞化学研究显示，在 20 名 NBD 患者中的 13 名和 20 名 BD 患者中的 6 名的血清和/或脑脊液（CSF）中存在针对海马和小脑分子层以及培养的海马神经元表面抗原的抗体，但多发性硬化症或头痛对照组中不存在。使用蛋白质宏阵列进行筛选导致鉴定应激诱导磷蛋白-1（STIP-1）作为抗原靶标。在 6 名 NBD 患者的血清中检测到高滴度的 STIP-1 抗体，但在对照组中未检测到。这些结果表明神经元抗体可用作 NBD 的诊断生物标志物。
