Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.
J Neuroimmunol. 2013 Oct 15;263(1-2):139-44. doi: 10.1016/j.jneuroim.2013.08.007. Epub 2013 Aug 24.
Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation.
针对神经白塞病（NBD）的诊断自身抗体的鉴定工作均以失败告终。通过蛋白宏阵列对 NBD 患者血清进行筛查，发现线粒体载体家族 1 蛋白（Mtch1）是一种与凋亡相关的蛋白，可作为一种潜在的自身抗原。ELISA 研究显示，144 例有或无神经受累的 BD 患者中有 68 例、168 例对照中有 4 例血清 Mtch1 抗体呈阳性，其敏感性为 47.2%，特异性为 97.6%。Mtch1 抗体阳性的 NBD 患者发作次数更多、残疾程度更高、血清核小体水平更低。Mtch1 抗体可能参与了 NBD 的发病机制，而不仅仅是自身炎症的偶然副产物。
