Institute of Physics, Wroclaw University of Technology, Wroclaw, Poland.
Eye Contact Lens. 2011 Nov;37(6):342-7. doi: 10.1097/ICL.0b013e31822e8df2.
Evaluating precorneal tear film is one of important clinical measurements for assessing health of anterior eye. Contact lens wear is known to influence the quality of tear film. The aim was to evaluate the applicability of lateral shearing interferometry technique in the noninvasive assessment of the effects of contact lens replacement modality and its water content on tear film stability.
Sixteen regular soft contact lens wearers took place in the study. Lateral shearing interferometry measurements, in suppressed blinking conditions, were taken in the mornings and afternoons, after a minimum of 5 hours of lens wear for the daily lenses, and after 2 weeks and 1 month for the fortnightly and monthly lens replacement modalities, respectively.
Significant differences (paired bootstrap-based Behrens-Fisher test, P < 0.05) in the tear film surface quality were found between all considered pairs of replacement modalities except for the daily and fortnightly lenses measured in the afternoon of the first day of wear. Significant worsening (paired bootstrap-based Behrens-Fisher test, P < 0.001) of tear film quality was found for the low water content materials.
Lateral shearing interferometry is a powerful method for the noninvasive assessment of tear film surface quality on soft contact lenses that may find, in future, its use in the clinical assessment of anterior eye's health.
评估角膜前泪膜是评估眼前部健康的重要临床测量方法之一。已知隐形眼镜的佩戴会影响泪膜的质量。本研究旨在评估侧向剪切干涉技术在非侵入性评估隐形眼镜更换方式及其含水量对泪膜稳定性的影响方面的适用性。
本研究纳入了 16 名常规软性隐形眼镜佩戴者。在抑制眨眼的情况下，在佩戴隐形眼镜 5 小时后（对于日戴型镜片），以及更换镜片 2 周和 1 个月后（对于两周和一个月更换方式的镜片）的上午和下午，分别进行侧向剪切干涉测量。
除了第一天佩戴时下午测量的日戴型和两周更换型镜片外，所有更换方式之间的泪膜表面质量均存在显著差异（基于 bootstrap 的 Behrens-Fisher 检验，P < 0.05）。低含水量材料的泪膜质量显著恶化（基于 bootstrap 的 Behrens-Fisher 检验，P < 0.001）。
侧向剪切干涉技术是一种用于评估软性隐形眼镜泪膜表面质量的强大方法，未来可能会在眼前部健康的临床评估中得到应用。
