32例发生血栓事件的新生儿的管理与转归
Management and outcome in 32 neonates with thrombotic events.
作者信息
van Elteren H A, Veldt H S, Te Pas A B, Roest A A W, Smiers F J, Kollen W J, Sramek A, Walther F J, Lopriore E
机构信息
Division of Neonatology, Department of Pediatrics, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
出版信息
Int J Pediatr. 2011;2011:217564. doi: 10.1155/2011/217564. Epub 2011 Aug 11.
Abstract
Objective. To determine the incidence, management, complications, and outcome in neonates with thrombotic events. Study Design. We performed a retrospective study of all neonates with thrombotic events admitted to our neonatal intensive care unit from January 2004 to July 2010. Results. Thrombotic events were identified in 32 of 4734 neonates (0.7%). Seven neonates were managed expectantly and 25 neonates received anticoagulant treatment. Complete resolution of the clot within 3 months of age was found in 68% (17/25) of the treated and in 86% (6/7) of the nontreated neonates. Major complications due to anticoagulant therapy occurred in 3/25 cases (12%) and included severe hemorrhage (n = 2) and abscess at the injection site (n = 1). Conclusion. Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group. Randomized controlled trials are warranted to determine the optimal management in neonatal thrombosis.
摘要
目的。确定新生儿血栓形成事件的发生率、管理方法、并发症及转归。研究设计。我们对2004年1月至2010年7月入住我院新生儿重症监护病房的所有发生血栓形成事件的新生儿进行了一项回顾性研究。结果。在4734例新生儿中有32例（0.7%）发生了血栓形成事件。7例新生儿采取观察等待处理，25例新生儿接受了抗凝治疗。在接受治疗的新生儿中，68%（17/25）在3月龄内血栓完全溶解，在未接受治疗的新生儿中这一比例为86%（6/7）。抗凝治疗导致的主要并发症发生在3/25例（12%），包括严重出血（n = 2）和注射部位脓肿（n = 1）。结论。治疗组和未治疗组新生儿血栓均有完全或部分溶解的情况。需要进行随机对照试验以确定新生儿血栓形成的最佳管理方法。
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