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低分子量肝素用于早产儿后出现严重血肿。

Severe hematoma following the use of low molecular weight heparin in preterm neonate.

作者信息

Durrani Naveed Ur Rehman, Elfaki Elhindi, Sigola Nqobile Tessa, Tscherning Charlotte, Gupta Samir, Glass Graeme E, Yajamanyum Phani Kiran

机构信息

Division of Neonatology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.

Department of Pediatrics, Weill Cornell Medicine - Qatar, Doha, Qatar.

出版信息

Case Rep Perinat Med. 2022 May 26;11(1):20210086. doi: 10.1515/crpm-2021-0086. eCollection 2022 Jan.

DOI:10.1515/crpm-2021-0086
PMID:40041234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11800662/
Abstract

OBJECTIVES

With the increased survival of preterm neonates, thromboembolic (TE) events are increasingly being recognized due to the use of indwelling catheters. It is still debatable to treat TE with low molecular weight heparin (LMWH) or follow expectant management. Despite the safety and efficacy profile about using LMWH in adults, its use in extreme preterm neonates with TE events is limited. The therapeutic level and pharmacokinetics of LMWH in the preterm population are relatively variable.

CASE PRESENTATION

We present a case with a severe hematoma on the left thigh following the use of LMWH, which was surgically drained and had a successful skin graft.

CONCLUSIONS

This case highlights the importance of early and close monitoring of injection sites in patients treated with LMWH.

摘要

目的

随着早产儿存活率的提高，由于留置导管的使用，血栓栓塞（TE）事件越来越受到关注。对于TE是使用低分子量肝素（LMWH）治疗还是采取期待性管理仍存在争议。尽管LMWH在成人中使用具有安全性和有效性，但在患有TE事件的极早产儿中的应用有限。LMWH在早产人群中的治疗水平和药代动力学相对多变。

病例报告

我们报告一例使用LMWH后左大腿出现严重血肿的病例，该血肿经手术引流并成功进行了植皮。

结论

本病例强调了对接受LMWH治疗的患者早期密切监测注射部位的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40aa/11800662/a89d332215dc/j_crpm-2021-0086_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40aa/11800662/cab3a334f044/j_crpm-2021-0086_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40aa/11800662/a89d332215dc/j_crpm-2021-0086_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40aa/11800662/cab3a334f044/j_crpm-2021-0086_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40aa/11800662/a89d332215dc/j_crpm-2021-0086_fig_002.jpg

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Neonatology. 2011;99(4):247-9. doi: 10.1159/000316934. Epub 2010 Nov 9.
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