HLA - B57和性别影响印度南部HIV感染者中结核病的发生。
HLA-B57 and gender influence the occurrence of tuberculosis in HIV infected people of south India.
作者信息
Jagannathan Latha, Chaturvedi Mrinalini, Satish Bhuthaiah, Satish Kadappa Shivappa, Desai Anita, Subbakrishna D K, Satishchandra Parthasarathy, Pitchappan Ramasamy, Balakrishnan Kamala, Kondaiah Paturu, Ravi Vasanthapuram
机构信息
Rotary-TTK Blood Bank, Bangalore Medical Services Trust, Bangalore, India.
出版信息
Clin Dev Immunol. 2011;2011:549023. doi: 10.1155/2011/549023. Epub 2011 Aug 25.
BACKGROUND
Substantial evidence exists for HLA and other host genetic factors being determinants of susceptibility or resistance to infectious diseases. However, very little information is available on the role of host genetic factors in HIV-TB coinfection. Hence, a longitudinal study was undertaken to investigate HLA associations in a cohort of HIV seropositive individuals with and without TB in Bangalore, South India.
METHODS
A cohort of 238 HIV seropositive subjects were typed for HLA-A, B, and DR by PCR-SSP and followed up for 5 years or till manifestation of Tuberculosis. HLA data of 682 HIV Negative healthy renal donors was used as control.
RESULTS
The ratio of males and females in HIV cohort was comparable (50.4% and 49.6%). But the incidence of TB was markedly lower in females (12.6%,) than males (25.6%). Further, HLA-B*57 frequency in HIV cohort was significantly higher among females without TB (21.6%, 19/88) than males (1.7%, 1/59); P = 0.0046; OR = 38. CD4 counts also were higher among females in this cohort.
CONCLUSION
This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males.
背景
有大量证据表明，人类白细胞抗原（HLA）和其他宿主遗传因素是决定对传染病易感性或抵抗力的因素。然而，关于宿主遗传因素在HIV-TB合并感染中的作用，目前所知甚少。因此，开展了一项纵向研究，以调查印度南部班加罗尔一组感染HIV且合并或未合并结核病的个体中的HLA相关性。
方法
通过聚合酶链反应-序列特异性引物（PCR-SSP）对238名HIV血清阳性受试者进行HLA-A、B和DR分型，并随访5年或直至结核病出现。将682名HIV阴性健康肾脏供体的HLA数据用作对照。
结果
HIV队列中男性和女性的比例相当（分别为50.4%和49.6%）。但女性结核病发病率（12.6%）明显低于男性（25.6%）。此外，在未患结核病的女性HIV队列中，HLA-B*57频率（21.6%，19/88）显著高于男性（1.7%，1/59）；P = 0.0046；比值比（OR）= 38。该队列中女性的CD4细胞计数也较高。
结论
本研究表明，与男性相比，携带HLA-B*57的HIV阳性女性患结核病的几率更低。
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