Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Clinics (Sao Paulo). 2011;66(7):1259-66. doi: 10.1590/s1807-59322011000700023.
Peripheral nerves are often damaged by direct mechanical injury, diseases, and tumors. The peripheral nerve injuries that result from these conditions can lead to a partial or complete loss of motor, sensory, and autonomic functions, which in turn are related to changes in skin temperature, in the involved segments of the body. The aim of this study was to evaluate the changes in hind paw skin temperature after sciatic nerve crush in rats in an attempt to determine whether changes in skin temperature correlate with the functional recovery of locomotion.
Wistar rats were divided into three groups: control (n = 7), sham (n = 25), and crush (n = 25). All groups were subjected to thermographic, functional, and histological assessments.
ΔT in the crush group was different from the control and sham groups at the 1st, 3rd and 7rd postoperative days (p<0.05). The functional recovery from the crush group returned to normal values between the 3rd and 4th week post-injury, and morphological analysis of the nerve revealed incomplete regeneration at the 4th week after injury.
This study is the first demonstration that sciatic nerve crush in rats induces an increase in hind paw skin temperature and that skin temperature changes do not correlate closely with functional recovery.
外周神经经常因直接机械损伤、疾病和肿瘤而受损。这些情况下的外周神经损伤可导致运动、感觉和自主功能部分或完全丧失，这反过来又与体温变化有关，与身体受影响的部位有关。本研究旨在评估大鼠坐骨神经挤压后后爪皮肤温度的变化，试图确定皮肤温度的变化是否与运动功能的恢复相关。
Wistar 大鼠分为三组：对照组（n=7）、假手术组（n=25）和挤压组（n=25）。所有组均进行热成像、功能和组织学评估。
挤压组在术后第 1、3 和 7 天的 ΔT 与对照组和假手术组不同（p<0.05）。挤压组的功能恢复在损伤后第 3 至第 4 周恢复正常，神经形态学分析显示损伤后第 4 周神经不完全再生。
本研究首次证明大鼠坐骨神经挤压会导致后爪皮肤温度升高，且皮肤温度变化与功能恢复相关性不大。
