巴西复发缓解型和原发进展型多发性硬化症患者的不同认知特征。

Different cognitive profiles of Brazilian patients with relapsing-remitting and primary progressive multiple sclerosis.

作者信息

Rodrigues Dóra-Neide, Paes Renata Alves, Vasconcelos Claudia Cristina Ferreira, Landeira-Fernandez Jesus, Alvarenga Maria Papais

机构信息

Neurologia pela UNIRIO, Trabalho desenvolvido no Programa de Pós-Graduação em Neurologia, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rio de Janeiro RJ, Brazil.

出版信息

Arq Neuropsiquiatr. 2011 Aug;69(4):590-5. doi: 10.1590/s0004-282x2011000500004.

DOI:10.1590/s0004-282x2011000500004

PMID:21877025

Abstract

UNLABELLED

Cognitive impairment is a symptom of multiple sclerosis (MS). Different clinical forms of multiple sclerosis have different cognitive profiles, according to findings of previous studies which used extensive batteries of neuropsychological tests.

OBJECTIVE

To investigate cognitive profiles of Brazilian patients with relapsing-remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) by using a brief battery of neuropsychological tests.

METHOD

Sixty-six patients, within 18-65 of age and 3-18 years of education, were paired with healthy control subjects, regarding gender, age, and education level.

RESULTS

On Symbol Digit Modalities Test and Hooper Visual Organization Test, cognition was affected in 50% in RRMS and 69% in PPMS. Fluency of "F" was impaired in 24% of RRMS and 81% of PPMS. Immediate recall was affected in 32% of RRMS and in 63% of PPMS; whereas late recall, in 46% of relapsing-remitting and in 69% of primary progressive.

CONCLUSION

Cognitive profiles of relapsing-remitting and primary progressive patients are different.

摘要

未标注

认知障碍是多发性硬化症（MS）的一种症状。根据以往使用大量神经心理学测试组合的研究结果，多发性硬化症的不同临床形式具有不同的认知特征。

目的

通过使用一组简短的神经心理学测试，调查巴西复发缓解型多发性硬化症（RRMS）和原发进展型多发性硬化症（PPMS）患者的认知特征。

方法

66名年龄在18至65岁之间、受教育年限为3至18年的患者，按照性别、年龄和教育水平与健康对照者配对。

结果

在符号数字模式测试和胡珀视觉组织测试中，RRMS患者中有50%、PPMS患者中有69%的认知受到影响。RRMS患者中有24%、PPMS患者中有81%的“F”流畅性受损。RRMS患者中有32%、PPMS患者中有63%的即时回忆受到影响；而延迟回忆方面，复发缓解型患者中有46%、原发进展型患者中有69%受到影响。