低级别胶质瘤和高级别胶质瘤患者的认知障碍
Cognitive impairments in patients with low grade gliomas and high grade gliomas.
作者信息
Miotto Eliane C, Junior Aluizio Silva, Silva Clemar Corrêa, Cabrera Hector Navarro, Machado Melissa A R, Benute Glaucia R G, Lucia Mara C S, Scaff Milberto, Teixeira Manoel Jacobsen
机构信息
Department of Neurology, Hospital das Clinicas, University of São Paulo, Medical School, São Paulo SP, Brazil.
出版信息
Arq Neuropsiquiatr. 2011 Aug;69(4):596-601. doi: 10.1590/s0004-282x2011000500005.
OBJECTIVE
The relationship between brain tumors and cognitive deficits is well established in the literature. However, studies investigating the cognitive status in low and high-grade gliomas patients are scarce, particularly in patients with average or lower educational level. This study aimed at investigating the cognitive functioning in a sample of patients with low and high-grade gliomas before surgical intervention.
METHOD
The low-grade (G1, n=19) and high-grade glioma (G2, n=8) patients underwent a detailed neuropsychological assessment of memory, executive functions, visuo-perceptive and visuo-spatial abilities, intellectual level and language.
RESULTS
There was a significant impairment on verbal and visual episodic memory, executive functions including mental flexibility, nominal and categorical verbal fluency and speed of information processing in G2. G1 showed only specific deficits on verbal and visual memory recall, mental flexibility and processing speed.
CONCLUSION
These findings demonstrated different levels of impairments in the executive and memory domains in patients with low and high grade gliomas.
目的
脑肿瘤与认知缺陷之间的关系在文献中已有充分记载。然而，针对低级别和高级别胶质瘤患者认知状况的研究较少，尤其是教育水平处于平均水平或较低水平的患者。本研究旨在调查低级别和高级别胶质瘤患者样本在手术干预前的认知功能。
方法
低级别（G1，n = 19）和高级别胶质瘤（G2，n = 8）患者接受了关于记忆、执行功能、视觉感知和视觉空间能力、智力水平及语言的详细神经心理学评估。
结果
G2患者在言语和视觉情景记忆、执行功能（包括心理灵活性、命名和分类言语流畅性以及信息处理速度）方面存在显著损害。G1仅在言语和视觉记忆回忆、心理灵活性及处理速度方面存在特定缺陷。
结论
这些发现表明低级别和高级别胶质瘤患者在执行和记忆领域存在不同程度的损害。
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