Wolff F, Bolte A
Universität Frauenklinik Köln
Geburtshilfe Frauenheilkd. 1990 Mar;50(3):171-6. doi: 10.1055/s-2007-1026458.
Morbidity and mortality of low-weight infants depend mainly on the respiratory-distress syndrome (RDS) and its complications, such as neonatal asphyxia and intraventricular haemorrhage. This underlines the importance of prenatal prevention of RDS. The results of the present multicentre studies demonstrate successful acceleration of fetal lung maturation by glucocorticoids and ambroxol. Both agents lower the RDS-rate two to threefold. The effectiveness in accelerating fetal lung maturation is comparable. In contrast to glucocorticoids, ambroxol seems to have no severe potential maternal or fetal side effects. We believe that prenatal prevention of RDS remains the treatment of choice even if neonatal surfactant therapy is expected to open up new aspects for the future.
低体重婴儿的发病率和死亡率主要取决于呼吸窘迫综合征（RDS）及其并发症，如新生儿窒息和脑室内出血。这凸显了产前预防RDS的重要性。本多中心研究结果表明，糖皮质激素和氨溴索可成功加速胎儿肺成熟。两种药物均可使RDS发生率降低两到三倍。在加速胎儿肺成熟方面的效果相当。与糖皮质激素不同，氨溴索似乎没有严重的潜在母体或胎儿副作用。我们认为，即使预计新生儿表面活性剂疗法将为未来开辟新的方向，产前预防RDS仍是首选治疗方法。
