Dallaire-Dufresne Stéphanie, Paquet Valérie E, Charette Steve J
Institut de biologie intégrative et des systèmes, Pavillon Charles-Eugène-Marchand, Université Laval, 1030 avenue de la Médecine, Québec, QC G1V 0A6, Canada.
Can J Microbiol. 2011 Sep;57(9):699-707. doi: 10.1139/w11-072.
The amoeba Dictyostelium discoideum, a bacterial predator, has emerged as a valuable tool for studying bacterial virulence. All its features make this unicellular eukaryote a versatile model organism. It can be used to study virulence factors of pathogenic bacteria as well as host elements involved in resistance to pathogens. The virulence of more than 20 bacterial species pathogenic for humans or animals has been studied using D. discoideum so far. These bacteria are either extracellular or intracellular pathogens. This review presents an overview of the question, with special emphasis on the reasons why D. discoideum is a suitable host model to study bacterial virulence, as well as on the type of information on host–pathogen relationship this amoeba can provide.
盘基网柄菌，一种细菌捕食者，已成为研究细菌毒力的重要工具。它的所有特性使这种单细胞真核生物成为一种多功能的模式生物。它可用于研究病原菌的毒力因子以及参与抵抗病原体的宿主成分。迄今为止，已经使用盘基网柄菌研究了20多种对人类或动物致病的细菌的毒力。这些细菌要么是胞外病原体，要么是胞内病原体。本综述概述了这个问题，特别强调了盘基网柄菌为何是研究细菌毒力的合适宿主模型的原因，以及这种变形虫能够提供的关于宿主 - 病原体关系的信息类型。
