Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
Arch Pathol Lab Med. 2011 Sep;135(9):1092-6. doi: 10.5858/2010-0325-RSR.1.
Antiphospholipid antibodies are directed against phospholipid-protein complexes and include lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. Antiphospholipid antibody syndrome is a common cause of acquired thrombophilia and is characterized by venous or arterial thromboembolism or pregnancy morbidity and the presence of antiphospholipid antibodies. Antibodies should be demonstrable on at least 2 occasions separated by 12 weeks. Heterogeneity of the autoantibodies and absence of gold standard assays makes interpretation of laboratory results a challenge for both laboratorians and clinicians. This review discusses the key laboratory and clinical aspects of antiphospholipid antibody syndrome. Particular focus is given to lupus anticoagulant detection, in view of recently updated laboratory guidelines.
抗磷脂抗体是针对磷脂-蛋白复合物的，包括狼疮抗凝物、抗心磷脂抗体和抗β2-糖蛋白 I 抗体。抗磷脂抗体综合征是获得性血栓形成的常见原因，其特征是静脉或动脉血栓栓塞或妊娠并发症以及抗磷脂抗体的存在。抗体应至少在 2 次相隔 12 周的情况下可检测到。自身抗体的异质性和缺乏金标准检测方法使得实验室结果的解释对实验室人员和临床医生都是一个挑战。这篇综述讨论了抗磷脂抗体综合征的关键实验室和临床方面。鉴于最近更新的实验室指南，特别关注狼疮抗凝物的检测。
