Maksimov M L, Ermolaeva A S, Dralova O V
Kardiologiia. 2011;51(7):58-64.
Hypertension is one of the most common cardiovascular diseases. The development and progression of hypertension is associated with prolonged hyper activation of the renin-angiotensin-aldosterone system. ACE inhibitors and angiotensin receptor blockers (ARBs) are highly effective medicines and are widely used in the treatment of cardiovascular diseases: hypertension, congestive heart failure, coronary heart disease. The main pharmacological effects of ACE inhibitors and ARBs are hypotensive, neurohumoral, antiproliferative, cardio- and nefroprotective functions, as well as constantly improving endothelial function. In accordance with the article, hypertensive effectiveness, tolerability and organ-protective properties of valsartan are noticeable among patients with hypertension, obesity and erectile dysfunction, taking this medicine.
高血压是最常见的心血管疾病之一。高血压的发生和发展与肾素-血管紧张素-醛固酮系统的长期过度激活有关。血管紧张素转换酶抑制剂(ACE抑制剂)和血管紧张素受体阻滞剂(ARBs)是高效药物,广泛用于治疗心血管疾病:高血压、充血性心力衰竭、冠心病。ACE抑制剂和ARBs的主要药理作用是降压、神经体液调节、抗增殖、心脏和肾脏保护功能,以及持续改善内皮功能。根据文章,缬沙坦在患有高血压、肥胖和勃起功能障碍的患者中具有显著的降压效果、耐受性和器官保护特性。