Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
EMBO J. 2011 Aug 31;30(17):3516-26. doi: 10.1038/emboj.2011.269.
Universal trafficking components within the cell can be recruited to coordinate and regulate the developmental signalling cascades. We will present ways in which the intracellular trafficking machinery is used to affect and modulate the outcome of signal transduction in developmental contexts, thus regulating multicellular development. Each of the signalling components must reach its proper intracellular destination, in a form that is properly folded and modified. In many instances, the ability to bring components together or segregate them into distinct compartments within the cell actually provides the switch mechanism to turn developmental signalling pathways on or off. The review will begin with a focus on the signal-sending cells, and the ways in which ligand trafficking can impinge on the signalling outcome, via processing, endocytosis and recycling. We will then turn to the signal-receiving cell, and discuss mechanisms by which endocytosis can affect the spatial features of the signal, and the compartmentalization of components downstream to the receptor.
细胞内的通用运输组件可以被招募来协调和调节发育信号级联反应。我们将介绍细胞内运输机制如何用于影响和调节发育背景下信号转导的结果，从而调节多细胞发育。每个信号组件都必须到达其适当的细胞内目的地，以适当折叠和修饰的形式。在许多情况下，将组件聚集在一起或将它们分离到细胞内的不同隔室中的能力实际上提供了打开或关闭发育信号通路的开关机制。该综述将首先关注信号发送细胞，以及配体运输如何通过加工、内吞作用和再循环来影响信号转导的结果。然后，我们将转向信号接收细胞，并讨论内吞作用如何影响信号的空间特征，以及受体下游组件的区室化。
