TBAI 催化的氨基吡啶与β-酮酯和 1,3-二酮的氧化偶联反应-咪唑并[1,2-a]吡啶的合成。
TBAI-catalyzed oxidative coupling of aminopyridines with β-keto esters and 1,3-diones-synthesis of imidazo[1,2-a]pyridines.
机构信息
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.
出版信息
Chem Commun (Camb). 2011 Oct 28;47(40):11333-5. doi: 10.1039/c1cc13568f. Epub 2011 Aug 30.
PMID:21879040
Abstract
TBAI could catalyze the direct oxidative C-N coupling of 2-aminopyridines with β-keto esters and 1,3-diones, which affords imidazo[1,2-a]pyridines as the products. The reaction was realized under metal-free conditions by using tert-butyl hydroperoxide (TBHP) as the oxidant.
摘要
TBAI 可以催化 2-氨基吡啶与β-酮酯和 1,3-二酮的直接氧化 C-N 偶联反应，得到咪唑并[1,2-a]吡啶作为产物。该反应在无金属条件下，以叔丁基过氧化氢（TBHP）为氧化剂实现。
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