Kotnik V
Laboratory of Cellular Immunology, Diagnostics of Complement System and Syphilis, Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.
Acta Dermatovenerol Alp Pannonica Adriat. 2011;20(1):3-11.
Complement is one of the most important mechanisms of natural resistance preventing infections in humans and animals. It is actively involved in the pathogenesis of several diseases, including skin diseases, characterized by the presence of autoantibodies, foreign microorganisms, altered tissue cells, and the presence of mannan. Complement is intended to kill invading microorganisms but it can also destroy the organism's own damaged or altered cells. It is characterized by vigorous activity and is also potentially harmful for the host if triggered in its own body. This review discusses the significance of complement activation for emerging skin diseases and highlights the importance of serological laboratory tests for the detection of complement system activity alterations in skin diseases such as pemphigus vulgaris, bullous pemphigoid, herpes gestationis, dermatitis herpetiformis, porphyria, urticaria, angioedema, cutaneous vasculitis, systemic lupus erythematosus, partial lipodystrophy, lichen planus, xeroderma pigmentosum, psoriasis, and recurrent cutaneous infections. Finally, we draw attention to the current potential for treating these diseases with complement inhibitors.
补体是人和动物预防感染的最重要的天然抵抗机制之一。它积极参与多种疾病的发病机制，包括以自身抗体、外来微生物、改变的组织细胞以及甘露聚糖的存在为特征的皮肤病。补体旨在杀死入侵的微生物，但它也可能破坏机体自身受损或改变的细胞。其特点是活性旺盛，如果在自身机体中被触发，对宿主也有潜在危害。本综述讨论了补体激活对新兴皮肤病的意义，并强调了血清学实验室检测对于检测诸如寻常型天疱疮、大疱性类天疱疮、妊娠疱疹、疱疹样皮炎、卟啉病、荨麻疹、血管性水肿、皮肤血管炎、系统性红斑狼疮、部分脂肪营养不良、扁平苔藓、着色性干皮病、银屑病和复发性皮肤感染等皮肤病中补体系统活性改变的重要性。最后，我们提请注意目前使用补体抑制剂治疗这些疾病的潜力。
