Department of Dermatology, Japanese Red Cross Medical Center, Shibuya-ku, Tokyo, Japan.
Acta Derm Venereol. 2012 Jan;92(1):54-6. doi: 10.2340/00015555-1185.
Merkel cell carcinoma (MCC), an aggressive skin cancer with neuroendocrine features, has been found to be associated with a new type of human polyomavirus called Merkel cell polyomavirus (MCV). Patients diagnosed with MCC have a significantly increased risk of a second primary cancer. We report here the first case of two primary MCCs arising on the face at different times, associated with MCV infection. The tumour on the patient's right cheek was surgically removed, followed by chemoradiation. After a 10-year tumour-free period, a new tumour developed on the patient's left cheek. Histological and immunohistochemical findings were consistent with MCC. The tumours had high MCV copy numbers and expressed large T antigen, which may play a major role in MCV-mediated carcinogenesis. This case highlights the close links between MCC and MCV.
默克尔细胞癌（Merkel cell carcinoma，MCC）是一种具有神经内分泌特征的侵袭性皮肤癌，与一种新型人类多瘤病毒——默克尔细胞多瘤病毒（Merkel cell polyomavirus，MCV）有关。诊断为 MCC 的患者发生第二种原发性癌症的风险显著增加。我们在此报告首例两例原发性 MCC 在不同时间发生在面部，与 MCV 感染有关。患者右侧脸颊的肿瘤已通过手术切除，随后进行了放化疗。在 10 年无肿瘤期后，患者左侧脸颊又出现了一个新的肿瘤。组织学和免疫组织化学检查结果与 MCC 一致。肿瘤的 MCV 拷贝数较高，并表达大 T 抗原，这可能在 MCV 介导的致癌作用中起主要作用。该病例突出了 MCC 与 MCV 之间的密切联系。
