Ash J, DeSouza M, Peters M, Wilmot D, Hausen D, Gilday D
Hospital for Sick Children, Toronto, Ontario, Canada.
J Nucl Med. 1990 May;31(5):580-5.
We applied a renal blood flow (RBF) quantification technique to pediatric data, which depends minimally on bolus shape, uses a conventional radiopharmaceutical 99mTc-DTPA, and generates a value for RBF as a percentage of cardiac output (RBF/CO). Mean RBF was 16.9% (+/- 4.8) for normal transplants, 13.1% (+/- 2.9) for transplants undergoing mild-to-moderate chronic rejection, 7.9% (+/- 1.3) for those with mild acute rejection and 3.3% (+/- 1.4) for those with moderate-to-severe acute rejection. Very low blood flow values within 24 hr following transplantation may have prognostic significance. Patients who required transplant-nephrectomy had significantly lower RBF/CO values than children who retained their allograft.
我们将一种肾血流量（RBF）定量技术应用于儿科数据，该技术对团注形状的依赖极小，使用传统放射性药物99mTc-DTPA，并生成肾血流量占心输出量百分比（RBF/CO）的数值。正常移植肾的平均肾血流量为16.9%（±4.8），轻度至中度慢性排斥反应的移植肾为13.1%（±2.9），轻度急性排斥反应的移植肾为7.9%（±1.3），中度至重度急性排斥反应的移植肾为3.3%（±1.4）。移植后24小时内极低的血流量值可能具有预后意义。需要进行移植肾切除术的患者的RBF/CO值显著低于保留同种异体移植物的儿童。
