Lear J L, Raff U, Jain R, Horgan J G
Division of Nuclear Medicine, University of Colorado Health Sciences Center, Denver 80262.
J Nucl Med. 1988 Oct;29(10):1656-61.
We developed an easily implemented clinical procedure for quantitative perfusion measurements in transplanted kidneys using intravenously administered [99mTc]DTPA and the tracer fractionation technique. F = Ak(T)/0 integral of T [Aa(t)/Va] dt, where F = renal blood flow, Ak(T) = DTPA activity in kidney at time = T, Va = ultrasonographically measured femoral artery segment volume, T = time postinjection of F determination, and Aa(t) = time course of DTPA activity in femoral artery segment. The technique was applied to a group of 80 studies in 35 patients in whom an independent clinical determination of transplant function was available. Blood flow (units of ml/min) measured 439 +/- 83 in normally functioning transplants, 248 +/- 63 in transplants with acute tubular necrosis, 128 +/- 62 in transplants with rejection, and 284 +/- 97 in transplants with cyclosporine toxicity. These preliminary results indicate potential usefulness of this method in the evaluation of renal function following transplant surgery.
我们开发了一种易于实施的临床程序，用于使用静脉注射的[99mTc]二乙三胺五乙酸（DTPA）和示踪剂分离技术对移植肾进行定量灌注测量。F = Ak(T)/0到T的积分[A a(t)/V a]dt，其中F =肾血流量，Ak(T) =时间T时肾内的DTPA活性，V a =超声测量的股动脉节段体积，T =注射F进行测定后的时间，A a(t) =股动脉节段中DTPA活性随时间的变化过程。该技术应用于35例患者的80项研究中，这些患者可进行移植功能的独立临床测定。正常功能移植肾的血流量（单位为ml/min）为439±83，急性肾小管坏死移植肾为248±63，排斥反应移植肾为128±62，环孢素毒性移植肾为284±97。这些初步结果表明该方法在评估移植肾术后肾功能方面具有潜在用途。
