Speight P M, Cruchley A, Williams D M
Department of Oral Pathology, London Hospital Medical College, England.
J Oral Pathol Med. 1990 Mar;19(3):126-30. doi: 10.1111/j.1600-0714.1990.tb00810.x.
Plasma cells expressing IgG, IgA and IgM were quantified in labial salivary glands from patients with Sjögren's syndrome (SS) and compared with glands showing non-specific inflammatory changes and normal controls. In all glands the predominant isotype was IgA but in SS there was a significant increase in both the number and proportions of IgG and IgM positive cells (P less than 0.002). In particular, all SS cases contained greater than 10% IgM positive cells (mean = 26.8 +/- 15.5). The results suggest that accumulation of IgM positive plasma cells may be a specific finding in SS and support the concept that the glandular lesions may be a site of B-cell clonal expansion. Since most B-cell hyperproliferative states in SS, including lymphoma, are associated with synthesis of IgM simple quantification of plasma cells may have important diagnostic and prognostic significance.
对干燥综合征（SS）患者唇腺中表达IgG、IgA和IgM的浆细胞进行定量，并与显示非特异性炎症变化的腺体及正常对照进行比较。在所有腺体中，主要的免疫球蛋白类型是IgA，但在干燥综合征患者中，IgG和IgM阳性细胞的数量和比例均显著增加（P<0.002）。特别是，所有干燥综合征病例中IgM阳性细胞均超过10%（平均值=26.8±15.5）。结果表明，IgM阳性浆细胞的积聚可能是干燥综合征的一个特异性表现，并支持腺体病变可能是B细胞克隆扩增部位的概念。由于干燥综合征中大多数B细胞过度增殖状态，包括淋巴瘤，都与IgM的合成有关，因此浆细胞的简单定量可能具有重要的诊断和预后意义。
