Hejazi Jalal, Mohtadinia Javad, Kolahi Soasan, Bakhtiyari Mahmood, Delpisheh Ali
Department of Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Womens Health (Lond). 2011 Sep;7(5):599-605. doi: 10.2217/whe.11.41.
Long-standing chronic diseases such as rheumatoid arthritis are known to be associated with impairment of nutritional status to some degree. The present study aimed to assess nutritional status of women with rheumatoid arthritis and compare their ingestion of certain micronutrients with dietary reference intakes.
In this cross-sectional study, 90 eligible women were recruited. After examination, all patients were evaluated on the basis of disease activity score, calculated using the number of tender and swollen joints, patient global assessment of pain and high sensitivity C-reactive protein (CRP). A three-day 24 h recall was completed and a 10 ml fasting blood sample was obtained to assess the plasma levels of malondialdehyde, total antioxidant and CRP.
Despite normal BMI, intake of energy and micronutrients including calcium, folic acid, zinc, magnesium and vitamin B6 were considerably lower compared with the dietary reference intakes. There was no significant relationship between intake of different nutrients or food groups and disease activity score and the biochemical markers including malondialdehyde, CRP and total antioxidant.
Intake of energy and some micronutrients were significantly lower than the recommended values. However, no relationship was found between intake of different food groups or nutrients with disease activity or serum antioxidant capacity.
诸如类风湿关节炎等长期慢性疾病已知在一定程度上与营养状况受损有关。本研究旨在评估类风湿关节炎女性的营养状况，并将她们某些微量营养素的摄入量与膳食参考摄入量进行比较。
在这项横断面研究中，招募了90名符合条件的女性。检查后，所有患者根据疾病活动评分进行评估，该评分使用压痛和肿胀关节数、患者对疼痛的整体评估以及高敏C反应蛋白（CRP）来计算。完成了为期三天的24小时饮食回顾，并采集了10毫升空腹血样以评估丙二醛、总抗氧化剂和CRP的血浆水平。
尽管体重指数正常，但能量以及包括钙、叶酸、锌、镁和维生素B6在内的微量营养素的摄入量与膳食参考摄入量相比显著更低。不同营养素或食物组的摄入量与疾病活动评分以及包括丙二醛、CRP和总抗氧化剂在内的生化标志物之间没有显著关系。
能量和一些微量营养素的摄入量显著低于推荐值。然而，未发现不同食物组或营养素的摄入量与疾病活动或血清抗氧化能力之间存在关联。
