病毒在猫下泌尿道疾病中的作用。

The role of viruses in feline lower urinary tract disease.

作者信息

Kruger J M, Osborne C A

机构信息

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul.

出版信息

J Vet Intern Med. 1990 Mar-Apr;4(2):71-8. doi: 10.1111/j.1939-1676.1990.tb03106.x.

DOI:10.1111/j.1939-1676.1990.tb03106.x

PMID:2187983

Abstract

Viruses have been implicated as causative agents in the etiopathogenesis of some forms of feline lower urinary tract disease (LUTD). This hypothesis was supported by isolation of feline calicivirus, bovine herpesvirus 4 (strain FeCAHV), and feline syncytia-forming virus from cats with naturally occurring LUTD, and by experimental studies of induced viral urinary tract infection. Results of early clinical studies yielded contradictory results concerning the role of viruses in feline LUTD. However, recent detection of bovine herpesvirus 4 antibodies in feline serum samples and discovery of calicivirus-like particles in crystalline/matrix urethral plugs obtained from cats with naturally occurring LUTD, suggests the need to reexamine the etiopathologic role of viruses using contemporary methods of virus identification and localization.

摘要

病毒被认为是某些形式的猫下泌尿道疾病（LUTD）发病机制中的致病因子。从患有自然发生的LUTD的猫中分离出猫杯状病毒、牛疱疹病毒4型（FeCAHV株）和猫融合形成病毒，以及对诱导性病毒尿路感染的实验研究，都支持了这一假设。早期临床研究的结果在病毒在猫LUTD中的作用方面产生了相互矛盾的结果。然而，最近在猫血清样本中检测到牛疱疹病毒4抗体，以及在从患有自然发生的LUTD的猫获得的结晶/基质尿道栓中发现杯状病毒样颗粒，表明需要使用当代病毒鉴定和定位方法重新审视病毒的病因学作用。