Kruger J M, Osborne C A, Goyal S M, Pomeroy K A, O'Brien T D
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
Am J Vet Res. 1990 Oct;51(10):1649-55.
Clinicopathologic manifestations of induced infection of the feline lower urinary tract with bovid herpesvirus-4 (BHV-4, strain FCAHV) were characterized in 6 conventionally reared adult cats (2 sexually intact males, 2 castrated males, and 2 females). Two additional control cats were exposed with noninfected cell culture control inoculum. Clinical and radiographic signs of lower urinary tract disease were not observed in exposed or control cats. Microscopic hematuria was detected in urine samples collected by cystocentesis from 4 to 6 exposed cats and 1 of 2 control cats. Results of culture of urine for bacteria, mycoplasmas, ureaplasmas, and viruses were consistently negative. Low titer of serum BHV-4 (strain FCAHV)-neutralizing antibodies was detected in 4 of 6 exposed cats, but not in controls. Gross abnormalities of the urinary tract were not observed in any cat. Light microscopic examination of serial sections of the lower urinary tract revealed mild focal lymphoid cystitis in 2 of 6 exposed cats, one of which also had increased amounts of connective tissue and proliferation of blood vessels in the urinary bladder lamina propria. Ninety days after initial exposure, BHV-4 (strain FCAHV) was reisolated from explanted urinary bladder tissues of 5 of 6 exposed cats. Virus was not isolated from tissues of control cats. It was concluded that BHV-4 (strain FCAHV) establishes persistent urinary tract infection in conventionally reared adult male and female cats. However, persistent BHV-4 infection in cats may remain clinically inapparent.
对6只常规饲养的成年猫（2只未绝育雄性、2只去势雄性和2只雌性）进行了牛疱疹病毒4型（BHV - 4，FCAHV毒株）诱发的猫下泌尿道感染的临床病理表现特征研究。另外2只对照猫接种未感染的细胞培养对照接种物。在接触病毒的猫或对照猫中未观察到下泌尿道疾病的临床和影像学症状。通过膀胱穿刺采集的尿液样本中，4至6只接触病毒的猫和2只对照猫中的1只检测到镜下血尿。尿液细菌、支原体、脲原体和病毒培养结果均为阴性。6只接触病毒的猫中有4只检测到低滴度的血清BHV - 4（FCAHV毒株）中和抗体，对照猫中未检测到。所有猫均未观察到泌尿道的肉眼异常。对下泌尿道连续切片进行光镜检查发现，6只接触病毒的猫中有2只出现轻度局灶性淋巴细胞性膀胱炎，其中1只猫的膀胱固有层结缔组织增多且血管增生。初次接触病毒90天后，6只接触病毒的猫中有5只的移植膀胱组织中重新分离出BHV - 4（FCAHV毒株）。对照猫的组织中未分离到病毒。得出的结论是，BHV - 4（FCAHV毒株）在常规饲养的成年雄性和雌性猫中建立了持续性泌尿道感染。然而，猫的持续性BHV - 4感染在临床上可能不明显。
