Paediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, Rue Willy-Donzé, Geneva, Switzerland.
Eur J Clin Invest. 2012 Mar;42(3):303-9. doi: 10.1111/j.1365-2362.2011.02583.x. Epub 2011 Aug 31.
Cardiovascular risk markers are related to micro-angiopathy in children with type 1 diabetes (T1DM), but there is no information about their relationship with blood pressure (BP) and endothelial function.
This was a case-control study including 29 children with T1DM (mean age 10·5 ± 2·7 years, disease duration: 3·8 ± 2·2 years) and 39 healthy controls (mean age: 9·8 ± 2·7 years). We assessed 24-h ambulatory BP, vascular function and serum level of lipids, vascular cell adhesion molecule-1 (VCAM-1; ICAM) and selectins (E-selectin; P-selectin).
The subject groups had similar physical characteristics and lipids level, except body mass index (BMI) which was higher in T1DM than in healthy children (18·6 ± 2·6 vs. 16·7 ± 2·5 kg/m(2), P = 0·003). Children with T1DM had increased 24 h diastolic BP z-score (0·62 ± 0·9 vs. -0·65 ± 0·8, P < 0·001), even after adjustment for BMI, as well as higher VCAM-1 concentration (492 ± 346 vs. 340 ± 225 ng/mL, P = 0·039) compared to healthy subjects. Diastolic BP z-scores were associated with disease duration, E-selectin and triglyceride levels in the T1DM group (P < 0·05). E-selectin was also related to triglycerides, otherwise there were no relationships between vascular function, markers and BP.
E-selectin, an early atherosclerosis biomarker, is positively associated with diastolic BP values in children with T1DM, despite relatively short disease duration.
心血管风险标志物与 1 型糖尿病（T1DM）儿童的微血管病变有关，但尚无关于其与血压（BP）和内皮功能关系的信息。
这是一项病例对照研究，纳入了 29 名 T1DM 患儿（平均年龄 10.5 ± 2.7 岁，病程：3.8 ± 2.2 年）和 39 名健康对照者（平均年龄：9.8 ± 2.7 岁）。我们评估了 24 小时动态血压、血管功能以及血脂、血管细胞黏附分子-1（VCAM-1；ICAM）和选择素（E-选择素；P-选择素）的血清水平。
两组受试者的身体特征和血脂水平相似，除了 T1DM 患儿的体重指数（BMI）高于健康儿童（18.6 ± 2.6 比 16.7 ± 2.5 kg/m2，P = 0.003）。T1DM 患儿 24 小时舒张压 z 评分升高（0.62 ± 0.9 比-0.65 ± 0.8，P < 0.001），即使在调整 BMI 后，也高于健康受试者，VCAM-1 浓度也较高（492 ± 346 比 340 ± 225 ng/mL，P = 0.039）。在 T1DM 组，舒张压 z 评分与病程、E-选择素和甘油三酯水平相关（P < 0.05）。E-选择素也与甘油三酯相关，否则血管功能、标志物与 BP 之间无关联。
尽管病程相对较短，早期动脉粥样硬化生物标志物 E-选择素与 T1DM 患儿的舒张压值呈正相关。
