Leonard M P, Canning D A, Epstein J I, Gearhart J P, Jeffs R D
Division of Pediatric Urology, James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland.
J Urol. 1990 Jun;143(6):1209-12. doi: 10.1016/s0022-5347(17)40227-8.
Although the technique of subureteral injection has been widely accepted as an alternative to reimplantation in the treatment of vesicoureteral reflux, the choice of the material to be used is controversial. We have used glutaraldehyde cross-linked bovine collagen to correct vesicoureteral reflux within the context of a Food and Drug Administration approved investigational study. We report the local tissue reaction to the implanted collagen in 7 patients who underwent reimplantation 3 to 19 months after failed endoscopic therapy. Glutaraldehyde cross-linked bovine collagen engendered a minimal localized inflammatory reaction without causing granuloma formation. Subsequent reimplantation was not hindered by the presence of the implant materials.
尽管输尿管下注射技术作为治疗膀胱输尿管反流的再植术替代方法已被广泛接受，但所用材料的选择仍存在争议。在食品药品监督管理局批准的一项研究中，我们使用戊二醛交联牛胶原蛋白来纠正膀胱输尿管反流。我们报告了7例患者在经内镜治疗失败3至19个月后接受再植术时，植入胶原蛋白后的局部组织反应。戊二醛交联牛胶原蛋白引发了最小程度的局部炎症反应，未形成肉芽肿。植入材料的存在并未妨碍后续的再植术。
