Oral and Pharyngeal Cancer Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD, United States.
Curr Opin Cell Biol. 2011 Dec;23(6):716-23. doi: 10.1016/j.ceb.2011.08.002. Epub 2011 Aug 29.
The integration of extrinsic and intrinsic signals is required to preserve the self-renewal and tissue regenerative capacity of adult stem cells, while protecting them from malignant conversion or loss of proliferative potential by death, differentiation or senescence. Here we review emerging signaling circuitries regulating stem cell fate, with emphasis on epithelial stem cells. Wnt, mTOR, GPCRs, Notch, Rho GTPases, YAP and DNA and histone methylases are some of the mechanisms that allow stem cells to balance their regenerative potential and the initiation of terminal differentiation programs, guaranteeing appropriate tissue homeostasis. Understanding the signaling circuitries regulating stem cell fate decisions might provide important insights into cancer initiation and numerous human pathologies that involve the progressive loss of tissue-specific adult stem cells.
需要整合外在和内在信号，以维持成年干细胞的自我更新和组织再生能力，同时防止它们通过死亡、分化或衰老而发生恶性转化或丧失增殖潜能。在这里，我们综述了调节干细胞命运的新兴信号通路，重点介绍了上皮干细胞。Wnt、mTOR、GPCRs、Notch、Rho GTPases、YAP 和 DNA 和组蛋白甲基转移酶是一些使干细胞能够平衡其再生潜能和启动终末分化程序的机制，从而保证适当的组织稳态。了解调节干细胞命运决定的信号通路可能为癌症的发生以及涉及特定组织的成年干细胞进行性丧失的许多人类病理提供重要的见解。
