同种异体干细胞移植后患者用 DAS181 治疗副流感 3 型感染。
Treatment of parainfluenza 3 infection with DAS181 in a patient after allogeneic stem cell transplantation.
机构信息
Bone Marrow Transplant Unit, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Clin Infect Dis. 2011 Oct;53(7):e77-80. doi: 10.1093/cid/cir501. Epub 2011 Aug 31.
PMID:21880586
Abstract
Parainfluenza virus (PIV) can cause significant morbidity after allogeneic stem cell transplantation (SCT). We report the first use of inhaled DAS181 for PIV in an allogeneic SCT recipient. Symptoms, oxygenation, and pulmonary function tests improved. Nasopharyngeal samples showed a reduction in viral load. DAS181 should be systematically evaluated for severe PIV infection.
摘要
副流感病毒（PIV）可导致异基因造血干细胞移植（SCT）后出现显著发病率。我们报告首例异基因 SCT 受者应用吸入用 DAS181 治疗 PIV。症状、氧合和肺功能检测均改善。鼻咽样本显示病毒载量降低。DAS181 治疗严重 PIV 感染应系统评估。
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