实体器官及造血干细胞移植中的呼吸道病毒感染
Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation.
作者信息
Paulsen Grant C, Danziger-Isakov Lara
机构信息
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, S8.216 MLC 7017, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, S8.216 MLC 7017, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
出版信息
Clin Chest Med. 2017 Dec;38(4):707-726. doi: 10.1016/j.ccm.2017.07.012. Epub 2017 Sep 20.
Abstract
Respiratory viruses are common in solid organ and hematopoietic stem cell transplant recipients and a recognized cause of significant morbidity and mortality. Epidemiology, risk factors, and attributable mortality in both populations are reviewed. In addition, virus-specific prevention and treatment options, including emerging investigational therapies, are discussed for respiratory syncytial virus, influenza, adenovirus, parainfluenza, and other respiratory viruses.
摘要
呼吸道病毒在实体器官移植受者和造血干细胞移植受者中很常见，是导致严重发病和死亡的一个公认原因。本文综述了这两类人群中的流行病学、危险因素和可归因死亡率。此外，还讨论了针对呼吸道合胞病毒、流感病毒、腺病毒、副流感病毒和其他呼吸道病毒的病毒特异性预防和治疗方案，包括新兴的研究性疗法。
相似文献
1
Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation.实体器官及造血干细胞移植中的呼吸道病毒感染
Clin Chest Med. 2017 Dec;38(4):707-726. doi: 10.1016/j.ccm.2017.07.012. Epub 2017 Sep 20.
2
Respiratory Fungal Infections in Solid Organ and Hematopoietic Stem Cell Transplantation.实体器官和造血干细胞移植中的肺部真菌感染。
Clin Chest Med. 2017 Dec;38(4):727-739. doi: 10.1016/j.ccm.2017.07.013. Epub 2017 Sep 28.
3
Viral infections in immunocompromised patients: what's new with respiratory viruses?免疫功能低下患者的病毒感染：呼吸道病毒有哪些新情况？
Curr Opin Infect Dis. 2002 Aug;15(4):355-67. doi: 10.1097/00001432-200208000-00002.
4
Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients.除季节性流感外，移植受者和非移植危重症患者社区获得性呼吸道病毒感染的特征。
J Microbiol Immunol Infect. 2021 Apr;54(2):253-260. doi: 10.1016/j.jmii.2019.05.007. Epub 2019 Jun 19.
5
Respiratory viral infections in transplant recipients.移植受者的呼吸道病毒感染
Antivir Ther. 2007;12(4 Pt B):627-38.
6
Viral Respiratory Tract Infections in Allogeneic Hematopoietic Stem Cell Transplantation Recipients in the Era of Molecular Testing.分子检测时代异基因造血干细胞移植受者的病毒呼吸道感染。
Biol Blood Marrow Transplant. 2018 Jul;24(7):1490-1496. doi: 10.1016/j.bbmt.2018.03.004. Epub 2018 Mar 9.
7
Mycobacterial Infections in Solid Organ and Hematopoietic Stem Cell Transplantation.实体器官和造血干细胞移植中的分枝杆菌感染。
Clin Chest Med. 2017 Dec;38(4):761-770. doi: 10.1016/j.ccm.2017.07.011. Epub 2017 Sep 20.
8
Pulmonary Impairment after Respiratory Viral Infections Is Associated with High Mortality in Allogeneic Hematopoietic Cell Transplant Recipients.呼吸道病毒感染后肺部损伤与异基因造血细胞移植受者的高死亡率相关。
Biol Blood Marrow Transplant. 2019 Apr;25(4):800-809. doi: 10.1016/j.bbmt.2018.11.022. Epub 2018 Dec 3.
9
Respiratory syncytial virus in hematopoietic cell transplant recipients and patients with hematologic malignancies.造血细胞移植受者和血液系统恶性肿瘤患者中的呼吸道合胞病毒。
Haematologica. 2019 Jul;104(7):1322-1331. doi: 10.3324/haematol.2018.215152. Epub 2019 Jun 20.
10
Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection.免疫功能低下患者的社区呼吸道病毒感染：造血干细胞和实体器官移植受者，以及人类免疫缺陷病毒感染者。
Semin Respir Crit Care Med. 2007 Apr;28(2):222-42. doi: 10.1055/s-2007-976494.
引用本文的文献
1
Respiratory viral infections in lung transplantation: Recent advances in epidemiology, clinical impact, and therapeutic approaches.肺移植中的呼吸道病毒感染：流行病学、临床影响及治疗方法的最新进展
JHLT Open. 2025 Aug 5;10:100362. doi: 10.1016/j.jhlto.2025.100362. eCollection 2025 Nov.
2
Isolation measures during the COVID-19 pandemic in transplant units may decrease respiratory infection rates and improve non-relapse mortality.新冠疫情期间移植单位采取的隔离措施可能会降低呼吸道感染率并改善非复发死亡率。
Bone Marrow Transplant. 2025 Jun 20. doi: 10.1038/s41409-025-02643-w.
3
Neutralizing Antibody Response to the AreXvy Respiratory Syncytial Virus Vaccine in Lung Transplant Recipients: Assessment Against Reference and Seasonal Strains.肺移植受者对AreXvy呼吸道合胞病毒疫苗的中和抗体反应：针对参考毒株和季节性毒株的评估
Vaccines (Basel). 2025 Apr 11;13(4):398. doi: 10.3390/vaccines13040398.
4
Disease Burden of RSV Infection in Adult Patients in Comparison to Influenza Virus Infection.与流感病毒感染相比，成人患者呼吸道合胞病毒感染的疾病负担
J Med Virol. 2025 May;97(5):e70373. doi: 10.1002/jmv.70373.
5
Respiratory Syncytial Virus Infections in Recipients of Bone Marrow Transplants: A Systematic Review and Meta-Analysis.骨髓移植受者的呼吸道合胞病毒感染：一项系统评价与荟萃分析
Infect Dis Rep. 2024 Mar 29;16(2):317-355. doi: 10.3390/idr16020026.
6
Impact of Respiratory Viral Infections in Transplant Recipients.移植受者呼吸道病毒感染的影响。
J Pediatric Infect Dis Soc. 2024 Feb 28;13(Supplement_1):S39-S48. doi: 10.1093/jpids/piad094.
7
Efficacy and Safety of Palivizumab as a Prophylaxis for Respiratory Syncytial Virus (RSV) Disease: An Updated Systemic Review and Meta-Analysis.帕利珠单抗预防呼吸道合胞病毒（RSV）疾病的疗效与安全性：一项更新的系统评价和荟萃分析
Cureus. 2023 Dec 31;15(12):e51375. doi: 10.7759/cureus.51375. eCollection 2023 Dec.
8
Prognostic Scores in Acute Liver Failure Due to Viral Hepatitis.病毒性肝炎所致急性肝衰竭的预后评分
Diagnostics (Basel). 2023 Mar 8;13(6):1035. doi: 10.3390/diagnostics13061035.
9
Linking the Center for International Blood and Marrow Transplant Research Registry to the California Cancer Registry and California Hospital Patient Discharge Data.将国际血液和骨髓移植研究中心注册处与加利福尼亚癌症登记处和加利福尼亚医院患者出院数据相链接。
Transplant Cell Ther. 2022 Dec;28(12):859.e1-859.e10. doi: 10.1016/j.jtct.2022.09.016. Epub 2022 Sep 27.
10
PCR-based diagnosis of respiratory virus in postsurgical septic patients: A preliminary study before SARS-CoV-2 pandemic.基于 PCR 的术后脓毒症患者呼吸道病毒诊断：SARS-CoV-2 流行前的初步研究。
Medicine (Baltimore). 2022 Aug 12;101(32):e29902. doi: 10.1097/MD.0000000000029902.
本文引用的文献
1
Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation.儿童造血细胞移植后免疫重建时的病毒激活及其相关结局。
J Allergy Clin Immunol. 2017 Dec;140(6):1643-1650.e9. doi: 10.1016/j.jaci.2016.12.992. Epub 2017 Apr 7.
2
Cytomegalovirus (CMV) DNA Quantitation in Bronchoalveolar Lavage Fluid From Hematopoietic Stem Cell Transplant Recipients With CMV Pneumonia.造血干细胞移植受者巨细胞病毒肺炎患者支气管肺泡灌洗术中巨细胞病毒（CMV）DNA定量分析
J Infect Dis. 2017 May 15;215(10):1514-1522. doi: 10.1093/infdis/jix048.
3
Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial.静脉注射扎那米韦或口服奥司他韦治疗流感住院患者：一项国际性、随机、双盲、双模拟、3 期临床试验。
Lancet Respir Med. 2017 Feb;5(2):135-146. doi: 10.1016/S2213-2600(16)30435-0. Epub 2017 Jan 14.
4
Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT.从干细胞或第三方供体中转移最小化处理的 CMV 特异性 T 细胞，以治疗 allo-HSCT 后 CMV 感染。
Leukemia. 2017 Oct;31(10):2161-2171. doi: 10.1038/leu.2017.16. Epub 2017 Jan 16.
5
Effective use of oral ribavirin for respiratory syncytial viral infections in allogeneic haematopoietic stem cell transplant recipients.在异基因造血干细胞移植受者中有效使用利巴韦林治疗呼吸道合胞病毒感染。
J Hosp Infect. 2017 Feb;95(2):214-217. doi: 10.1016/j.jhin.2016.11.012. Epub 2016 Nov 25.
6
Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial.布林西多福韦治疗儿童和成人异基因造血细胞移植受者无症状腺病毒血症：一项随机安慰剂对照II期试验
Biol Blood Marrow Transplant. 2017 Mar;23(3):512-521. doi: 10.1016/j.bbmt.2016.12.621. Epub 2017 Jan 5.
7
Compassionate use experience with high-titer respiratory syncytical virus (RSV) immunoglobulin in RSV-infected immunocompromised persons.高滴度呼吸道合胞病毒（RSV）免疫球蛋白在RSV感染的免疫功能低下人群中的同情用药经验。
Transpl Infect Dis. 2017 Apr;19(2). doi: 10.1111/tid.12657. Epub 2017 Mar 6.
8
Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation.帕拉米韦对携带神经氨酸酶H275Y突变的H5N1高致病性禽流感病毒的治疗效果。
Antiviral Res. 2017 Mar;139:41-48. doi: 10.1016/j.antiviral.2016.12.011. Epub 2016 Dec 22.
9
Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses.胆固醇降低剂可抑制I型副流感病毒的组装。
Virology. 2017 Jan 15;501:127-135. doi: 10.1016/j.virol.2016.11.011. Epub 2016 Dec 2.
10
Parainfluenza 3 Infections Early After Kidney or Simultaneous Pancreas-Kidney Transplantation.肾移植或胰肾联合移植术后早期的副流感病毒3型感染
Am J Transplant. 2017 Mar;17(3):809-812. doi: 10.1111/ajt.14146. Epub 2017 Jan 3.
Zotero 插件