鉴定出髓鞘少突胶质细胞糖蛋白是风疹病毒的细胞受体。
Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus.
机构信息
Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.
出版信息
J Virol. 2011 Nov;85(21):11038-47. doi: 10.1128/JVI.05398-11. Epub 2011 Aug 31.
Abstract
Rubella virus (RV) is a highly transmissible pathogenic agent that causes the disease rubella. Maternal RV infection during early pregnancy causes the death of the fetus or congenital rubella syndrome in infants. However, the cellular receptor for RV has not yet been identified. In this study, we found that the myelin oligodendrocyte glycoprotein (MOG) specifically bound to the E1 envelope glycoprotein of RV, and an antibody against MOG could block RV infection. Most importantly, we also showed that ectopic expression of MOG on the cell surface of 293T cells rendered this nonpermissive cell line permissive for RV entry and replication. Thus, this study has identified a cellular receptor for RV and suggests that blocking the MOG attachment site of RV may be a strategy for molecular intervention of RV infection.
摘要
风疹病毒（RV）是一种具有高度传染性的病原体，可引起风疹病。母体在妊娠早期感染 RV 会导致胎儿死亡或婴儿先天性风疹综合征。然而，RV 的细胞受体尚未被确定。在这项研究中，我们发现少突胶质细胞髓鞘糖蛋白（MOG）特异性结合 RV 的 E1 包膜糖蛋白，并且针对 MOG 的抗体可以阻断 RV 的感染。最重要的是，我们还表明，在 293T 细胞表面异位表达 MOG 使该非允许细胞系对 RV 的进入和复制变得允许。因此，本研究鉴定了 RV 的细胞受体，并表明阻断 RV 的 MOG 附着位点可能是 RV 感染的分子干预策略。
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