Pagany Maria, Jagodic Maja, Bourquin Carole, Olsson Tomas, Linington Christopher
Department of Neuroimmunology, Max-Planck Institute for Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany.
J Neuroimmunol. 2003 Jun;139(1-2):1-8. doi: 10.1016/s0165-5728(03)00124-3.
Myelin oligodendrocyte glycoprotein (MOG) is encoded within the RT1.M region of the rat MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis (EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG-EAE is associated with higher expression of MOG mRNA and protein in the nervous system than in the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune system, but there was no correlation with disease susceptibility. These results suggest that differences in the expression of MOG in the target organ, rather than in the immune system may influence susceptibility to MOG-EAE.
髓鞘少突胶质细胞糖蛋白（MOG）在大鼠主要组织相容性复合体（MHC）的RT1.M区域内编码，该区域是MOG诱导的实验性自身免疫性脑脊髓炎（EAE）的一个易感位点。我们报告，与不易感的Lewis（LEW）品系相比，Brown Norway（BN）大鼠对MOG-EAE的易感性增强与神经系统中MOG mRNA和蛋白的高表达有关。在免疫系统中也检测到了MOG mRNA，但与疾病易感性无关。这些结果表明，MOG在靶器官而非免疫系统中的表达差异可能影响对MOG-EAE的易感性。
