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Detection of Klebsiella pneumoniae carbapenemase (KPC) production in non-Klebsiella pneumoniae Enterobacteriaceae isolates by use of the Phoenix, Vitek 2, and disk diffusion methods.采用 Phoenix、Vitek 2 和纸片扩散法检测非肺炎克雷伯菌肠杆菌科分离株中产碳青霉烯酶的肺炎克雷伯菌（KPC）。
J Clin Microbiol. 2011 Mar;49(3):1143-7. doi: 10.1128/JCM.02163-10. Epub 2011 Jan 5.
2
Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae?我们能否使用亚胺培南和美罗培南 Vitek 2 MIC 来检测肠杆菌科中疑似的 KPC 和其他碳青霉烯酶产生菌？
J Clin Microbiol. 2011 Feb;49(2):697-701. doi: 10.1128/JCM.01178-10. Epub 2010 Dec 15.
3
Susceptibility profiles, molecular epidemiology, and detection of KPC-producing Escherichia coli isolates from the New York City vicinity.纽约市附近产 KPC 型大肠埃希菌的耐药谱、分子流行病学特征及检测
J Clin Microbiol. 2010 Dec;48(12):4604-7. doi: 10.1128/JCM.01143-10. Epub 2010 Oct 6.
4
Evaluation of updated interpretative criteria for categorizing Klebsiella pneumoniae with reduced carbapenem susceptibility.评价修订后用于分类碳青霉烯类药物敏感性降低的肺炎克雷伯菌的解释标准。
J Clin Microbiol. 2010 Dec;48(12):4417-25. doi: 10.1128/JCM.02458-09. Epub 2010 Sep 29.
5
Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.与产 KPC 肺炎克雷伯菌碳青霉烯类耐药升高相关的遗传因素。
Antimicrob Agents Chemother. 2010 Oct;54(10):4201-7. doi: 10.1128/AAC.00008-10. Epub 2010 Jul 26.
6
Comparison of meropenem MICs and susceptibilities for carbapenemase-producing Klebsiella pneumoniae isolates by various testing methods.不同检测方法检测产碳青霉烯酶肺炎克雷伯菌分离株的美罗培南 MIC 值和药敏结果比较。
J Clin Microbiol. 2010 Jul;48(7):2402-6. doi: 10.1128/JCM.00267-10. Epub 2010 May 19.
7
Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae.外膜孔蛋白K36对产KPC肺炎克雷伯菌碳青霉烯类药物敏感性的影响
J Med Microbiol. 2009 Oct;58(Pt 10):1303-1308. doi: 10.1099/jmm.0.012575-0. Epub 2009 Jun 25.
8
Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK.破坏英国产耐厄他培南克雷伯菌和肠杆菌临床分离株中孔蛋白表达的分子机制。
J Antimicrob Chemother. 2009 Apr;63(4):659-67. doi: 10.1093/jac/dkp029. Epub 2009 Feb 20.
9
Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA.在美国东部不同机构检测到的携带blaKPC的肺炎克雷伯菌分离株的特征分析。
J Antimicrob Chemother. 2009 Mar;63(3):427-37. doi: 10.1093/jac/dkn547. Epub 2009 Jan 20.
10
Specificity of ertapenem susceptibility screening for detection of Klebsiella pneumoniae carbapenemases.厄他培南敏感性筛查对检测肺炎克雷伯菌碳青霉烯酶的特异性
J Clin Microbiol. 2009 Mar;47(3):785-6. doi: 10.1128/JCM.02143-08. Epub 2009 Jan 14.

修订版 CLSI 折点用于检测携带 KPC 肠杆菌科细菌时，碳青霉烯类药物不敏感的准确性。

Accuracy of carbapenem nonsusceptibility for identification of KPC-possessing Enterobacteriaceae by use of the revised CLSI breakpoints.

机构信息

Division of Infectious Diseases, SUNY-Downstate, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.

出版信息

J Clin Microbiol. 2011 Nov;49(11):3931-3. doi: 10.1128/JCM.01176-11. Epub 2011 Aug 31.

DOI:10.1128/JCM.01176-11
PMID:21880962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3209089/
Abstract

Using the updated 2010 CLSI carbapenem breakpoints for the Enterobacteriaceae, nonsusceptibility to ertapenem and imipenem predicted the presence of bla(KPC) poorly, especially among Escherichia coli and Enterobacter species. In regions where KPC-producing bacteria are endemic, testing for nonsusceptibility to meropenem may provide improved accuracy in identifying these isolates.

摘要

采用更新的 2010 年 CLSI 碳青霉烯类药物药敏折点，对于肠杆菌科细菌，厄他培南和亚胺培南的耐药性并不能很好地预测 bla(KPC)的存在，尤其是在大肠埃希菌和肠杆菌属细菌中。在产 KPC 细菌流行的地区，检测美罗培南的耐药性可能会提高识别这些分离株的准确性。