修订版 CLSI 折点用于检测携带 KPC 肠杆菌科细菌时，碳青霉烯类药物不敏感的准确性。
Accuracy of carbapenem nonsusceptibility for identification of KPC-possessing Enterobacteriaceae by use of the revised CLSI breakpoints.
机构信息
Division of Infectious Diseases, SUNY-Downstate, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
出版信息
J Clin Microbiol. 2011 Nov;49(11):3931-3. doi: 10.1128/JCM.01176-11. Epub 2011 Aug 31.
Abstract
Using the updated 2010 CLSI carbapenem breakpoints for the Enterobacteriaceae, nonsusceptibility to ertapenem and imipenem predicted the presence of bla(KPC) poorly, especially among Escherichia coli and Enterobacter species. In regions where KPC-producing bacteria are endemic, testing for nonsusceptibility to meropenem may provide improved accuracy in identifying these isolates.
摘要
采用更新的 2010 年 CLSI 碳青霉烯类药物药敏折点，对于肠杆菌科细菌，厄他培南和亚胺培南的耐药性并不能很好地预测 bla(KPC)的存在，尤其是在大肠埃希菌和肠杆菌属细菌中。在产 KPC 细菌流行的地区，检测美罗培南的耐药性可能会提高识别这些分离株的准确性。
相似文献
1
Accuracy of carbapenem nonsusceptibility for identification of KPC-possessing Enterobacteriaceae by use of the revised CLSI breakpoints.修订版 CLSI 折点用于检测携带 KPC 肠杆菌科细菌时，碳青霉烯类药物不敏感的准确性。
J Clin Microbiol. 2011 Nov;49(11):3931-3. doi: 10.1128/JCM.01176-11. Epub 2011 Aug 31.
2
[Comparison of the modified Hodge test and the Carba NP test for detection of carbapenemases in Enterobacteriaceae isolates].[改良 Hodge 试验与 Carba NP 试验用于检测肠杆菌科分离株中碳青霉烯酶的比较]
Mikrobiyol Bul. 2016 Jan;50(1):1-10. doi: 10.5578/mb.10861.
3
Breakpoints for carbapenemase-producing Enterobacteriaceae: is the problem solved?产碳青霉烯酶肠杆菌科细菌的药敏折点：问题解决了吗？
Enferm Infecc Microbiol Clin. 2014 Dec;32 Suppl 4:33-40. doi: 10.1016/S0213-005X(14)70172-7.
4
Genotypic characterization and in vitro activities of tigecycline and polymyxin B for members of the Enterobacteriaceae with decreased susceptibility to carbapenems.碳青霉烯类药物敏感性降低的肠杆菌科成员的替加环素和多黏菌素 B 的基因型特征和体外活性。
J Med Microbiol. 2011 Dec;60(Pt 12):1813-1819. doi: 10.1099/jmm.0.025668-0. Epub 2011 Aug 11.
5
Comparative activities of doripenem versus isolates, mutants, and transconjugants of Enterobacteriaceae and Acinetobacter spp. with characterized beta-lactamases.多利培南对具有特征性β-内酰胺酶的肠杆菌科细菌和不动杆菌属细菌的分离株、突变株及接合子的比较活性
Antimicrob Agents Chemother. 2004 Apr;48(4):1313-9. doi: 10.1128/AAC.48.4.1313-1319.2004.
6
Presence of the KPC carbapenemase gene in Enterobacteriaceae causing bacteremia and its correlation with in vitro carbapenem susceptibility.导致菌血症的肠杆菌科细菌中KPC碳青霉烯酶基因的存在及其与体外碳青霉烯敏感性的相关性。
J Clin Microbiol. 2009 Jan;47(1):239-41. doi: 10.1128/JCM.02123-08. Epub 2008 Nov 19.
7
Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae.比较 BD Phoenix、Vitek 2 和 MicroScan 自动化系统在检测和推断肠杆菌科碳青霉烯类耐药机制中的作用。
J Clin Microbiol. 2010 Aug;48(8):2999-3002. doi: 10.1128/JCM.00341-10. Epub 2010 Jun 9.
8
[Carbapenem resistance in ESBL positive Enterobacteriaceae isolates causing invasive infections].[产超广谱β-内酰胺酶（ESBL）的肠杆菌科分离株引起侵袭性感染时对碳青霉烯类抗生素的耐药性]
Mikrobiyol Bul. 2014 Jan;48(1):59-69.
9
Carbapenem-Resistant Enterobacteriaceae Detection Practices in California: What Are We Missing?加州耐碳青霉烯肠杆菌科检测实践：我们遗漏了什么？
Clin Infect Dis. 2018 Mar 19;66(7):1061-1067. doi: 10.1093/cid/cix942.
10
[Investigation of carbapenemases in carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains isolated in 2014 in Turkey].[2014年在土耳其分离出的耐碳青霉烯类大肠杆菌和肺炎克雷伯菌菌株中碳青霉烯酶的调查]
Mikrobiyol Bul. 2016 Jan;50(1):21-33. doi: 10.5578/mb.10695.
引用本文的文献
1
Breakpoint beware: reliance on historical breakpoints for Enterobacteriaceae leads to discrepancies in interpretation of susceptibility testing for carbapenems and cephalosporins and gaps in detection of carbapenem-resistant organisms.注意：如果依赖于肠杆菌科的历史折点来解释碳青霉烯类和头孢菌素类药物的药敏试验，可能会导致结果解读不一致，并且可能会漏检耐碳青霉烯类的病原体。
Eur J Clin Microbiol Infect Dis. 2020 Jan;39(1):187-195. doi: 10.1007/s10096-019-03711-y. Epub 2019 Nov 2.
2
MALDI-TOF MS Identification and Clustering Applied to Species in Nosocomial Setting.基质辅助激光解吸电离飞行时间质谱鉴定与聚类分析在医院环境中细菌物种鉴定中的应用
Front Microbiol. 2018 Aug 14;9:1885. doi: 10.3389/fmicb.2018.01885. eCollection 2018.
3
Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms.产碳青霉烯酶肠杆菌属的全基因组分析：系统发育、种群结构和耐药机制的新见解
mBio. 2016 Dec 13;7(6):e02093-16. doi: 10.1128/mBio.02093-16.
4
Carbapenem-Resistant Enterobacteriaceae Infections in Children.儿童耐碳青霉烯类肠杆菌科细菌感染
Curr Infect Dis Rep. 2016 Jan;18(1):2. doi: 10.1007/s11908-015-0510-9.
5
Use of faropenem as an indicator of carbapenemase activity in the Enterobacteriaceae.使用法罗培南作为肠杆菌科碳青霉烯酶活性的指示剂。
J Clin Microbiol. 2013 Jun;51(6):1881-6. doi: 10.1128/JCM.00720-13. Epub 2013 Apr 10.
6
Does the piperacillin minimum inhibitory concentration for Pseudomonas aeruginosa influence clinical outcomes of children with pseudomonal bacteremia?铜绿假单胞菌哌拉西林最低抑菌浓度是否影响儿童假单胞菌菌血症的临床结局？
Clin Infect Dis. 2012 Sep;55(6):799-806. doi: 10.1093/cid/cis545. Epub 2012 Jun 13.
本文引用的文献
1
Detection of Klebsiella pneumoniae carbapenemase (KPC) production in non-Klebsiella pneumoniae Enterobacteriaceae isolates by use of the Phoenix, Vitek 2, and disk diffusion methods.采用 Phoenix、Vitek 2 和纸片扩散法检测非肺炎克雷伯菌肠杆菌科分离株中产碳青霉烯酶的肺炎克雷伯菌（KPC）。
J Clin Microbiol. 2011 Mar;49(3):1143-7. doi: 10.1128/JCM.02163-10. Epub 2011 Jan 5.
2
Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae?我们能否使用亚胺培南和美罗培南 Vitek 2 MIC 来检测肠杆菌科中疑似的 KPC 和其他碳青霉烯酶产生菌？
J Clin Microbiol. 2011 Feb;49(2):697-701. doi: 10.1128/JCM.01178-10. Epub 2010 Dec 15.
3
Susceptibility profiles, molecular epidemiology, and detection of KPC-producing Escherichia coli isolates from the New York City vicinity.纽约市附近产 KPC 型大肠埃希菌的耐药谱、分子流行病学特征及检测
J Clin Microbiol. 2010 Dec;48(12):4604-7. doi: 10.1128/JCM.01143-10. Epub 2010 Oct 6.
4
Evaluation of updated interpretative criteria for categorizing Klebsiella pneumoniae with reduced carbapenem susceptibility.评价修订后用于分类碳青霉烯类药物敏感性降低的肺炎克雷伯菌的解释标准。
J Clin Microbiol. 2010 Dec;48(12):4417-25. doi: 10.1128/JCM.02458-09. Epub 2010 Sep 29.
5
Genetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.与产 KPC 肺炎克雷伯菌碳青霉烯类耐药升高相关的遗传因素。
Antimicrob Agents Chemother. 2010 Oct;54(10):4201-7. doi: 10.1128/AAC.00008-10. Epub 2010 Jul 26.
6
Comparison of meropenem MICs and susceptibilities for carbapenemase-producing Klebsiella pneumoniae isolates by various testing methods.不同检测方法检测产碳青霉烯酶肺炎克雷伯菌分离株的美罗培南 MIC 值和药敏结果比较。
J Clin Microbiol. 2010 Jul;48(7):2402-6. doi: 10.1128/JCM.00267-10. Epub 2010 May 19.
7
Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae.外膜孔蛋白K36对产KPC肺炎克雷伯菌碳青霉烯类药物敏感性的影响
J Med Microbiol. 2009 Oct;58(Pt 10):1303-1308. doi: 10.1099/jmm.0.012575-0. Epub 2009 Jun 25.
8
Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK.破坏英国产耐厄他培南克雷伯菌和肠杆菌临床分离株中孔蛋白表达的分子机制。
J Antimicrob Chemother. 2009 Apr;63(4):659-67. doi: 10.1093/jac/dkp029. Epub 2009 Feb 20.
9
Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA.在美国东部不同机构检测到的携带blaKPC的肺炎克雷伯菌分离株的特征分析。
J Antimicrob Chemother. 2009 Mar;63(3):427-37. doi: 10.1093/jac/dkn547. Epub 2009 Jan 20.
10
Specificity of ertapenem susceptibility screening for detection of Klebsiella pneumoniae carbapenemases.厄他培南敏感性筛查对检测肺炎克雷伯菌碳青霉烯酶的特异性
J Clin Microbiol. 2009 Mar;47(3):785-6. doi: 10.1128/JCM.02143-08. Epub 2009 Jan 14.
Zotero 插件