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Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae?我们能否使用亚胺培南和美罗培南 Vitek 2 MIC 来检测肠杆菌科中疑似的 KPC 和其他碳青霉烯酶产生菌？
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2
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Int J Gen Med. 2019 Nov 28;12:437-446. doi: 10.2147/IJGM.S214305. eCollection 2019.
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4
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J Clin Microbiol. 2015 Jan;53(1):95-104. doi: 10.1128/JCM.01692-14. Epub 2014 Oct 29.
5
Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.肺炎克雷伯菌和其他肠杆菌科细菌中的碳青霉烯酶：具有全球范围的不断演变的危机。
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6
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Accuracy of carbapenem nonsusceptibility for identification of KPC-possessing Enterobacteriaceae by use of the revised CLSI breakpoints.修订版 CLSI 折点用于检测携带 KPC 肠杆菌科细菌时，碳青霉烯类药物不敏感的准确性。
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本文引用的文献

1
Extended-spectrum [beta]-lactamase producing Escherichia coli: changing epidemiology and clinical impact.产超广谱β-内酰胺酶大肠埃希菌：不断变化的流行病学和临床影响。
Curr Opin Infect Dis. 2010 Aug;23(4):320-6. doi: 10.1097/qco.0b013e3283398dc1.
2
A sensitive and specific phenotypic assay for detection of metallo-β-lactamases and KPC in Klebsiella pneumoniae with the use of meropenem disks supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin.一种利用美罗培南纸片补充氨苯硼酸、二吡啶甲酸和氯唑西林检测肺炎克雷伯菌中产金属β-内酰胺酶和 KPC 的敏感、特异表型检测方法。
Clin Microbiol Infect. 2011 Apr;17(4):552-6. doi: 10.1111/j.1469-0691.2010.03294.x.
3
Escherichia coli sequence type ST131 as the major cause of serious multidrug-resistant E. coli infections in the United States.大肠杆菌序列型 ST131 是导致美国严重的多药耐药大肠杆菌感染的主要原因。
Clin Infect Dis. 2010 Aug 1;51(3):286-94. doi: 10.1086/653932.
4
Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae.比较 BD Phoenix、Vitek 2 和 MicroScan 自动化系统在检测和推断肠杆菌科碳青霉烯类耐药机制中的作用。
J Clin Microbiol. 2010 Aug;48(8):2999-3002. doi: 10.1128/JCM.00341-10. Epub 2010 Jun 9.
5
Comparison of meropenem MICs and susceptibilities for carbapenemase-producing Klebsiella pneumoniae isolates by various testing methods.不同检测方法检测产碳青霉烯酶肺炎克雷伯菌分离株的美罗培南 MIC 值和药敏结果比较。
J Clin Microbiol. 2010 Jul;48(7):2402-6. doi: 10.1128/JCM.00267-10. Epub 2010 May 19.
6
Controlling false-positive results obtained with the Hodge and Masuda assays for detection of class a carbapenemase in species of enterobacteriaceae by incorporating boronic Acid.通过加入硼酸来控制霍奇和増田检测肠杆菌科细菌 A 类碳青霉烯酶时产生的假阳性结果。
J Clin Microbiol. 2010 Apr;48(4):1323-32. doi: 10.1128/JCM.01771-09. Epub 2010 Feb 24.
7
Infections with extended-spectrum beta-lactamase-producing enterobacteriaceae: changing epidemiology and drug treatment choices.产超广谱β-内酰胺酶肠杆菌科感染：不断变化的流行病学和药物治疗选择。
Drugs. 2010 Feb 12;70(3):313-33. doi: 10.2165/11533040-000000000-00000.
8
Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues.革兰氏阴性细菌病原体中获得性碳青霉烯酶：检测和监测问题。
Clin Microbiol Infect. 2010 Feb;16(2):112-22. doi: 10.1111/j.1469-0691.2009.03116.x.
9
Controlling the spread of carbapenemase-producing Gram-negatives: therapeutic approach and infection control.控制产碳青霉烯酶革兰氏阴性菌的传播：治疗方法和感染控制。
Clin Microbiol Infect. 2010 Feb;16(2):102-11. doi: 10.1111/j.1469-0691.2009.03115.x.
10
Updated functional classification of beta-lactamases.β-内酰胺酶的功能分类更新。
Antimicrob Agents Chemother. 2010 Mar;54(3):969-76. doi: 10.1128/AAC.01009-09. Epub 2009 Dec 7.

我们能否使用亚胺培南和美罗培南 Vitek 2 MIC 来检测肠杆菌科中疑似的 KPC 和其他碳青霉烯酶产生菌？

Can we use imipenem and meropenem Vitek 2 MICs for detection of suspected KPC and other-carbapenemase producers among species of Enterobacteriaceae?

机构信息

Servicio Antimicrobianos, Departamento Bacteriología, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Carlos G. Malbrán, Ministerio de Salud y Ambiente de la Nación, Ciudad Autónoma de Buenos Aires, Argentina.

出版信息

J Clin Microbiol. 2011 Feb;49(2):697-701. doi: 10.1128/JCM.01178-10. Epub 2010 Dec 15.

DOI:10.1128/JCM.01178-10
PMID:21159944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3043475/
Abstract

Imipenem and meropenem Vitek 2 MICs were evaluated for a panel of 104 Enterobacteriaceae for identification of carbapenemase producers. The sensitivity and specificity values for the new CLSI interpretative criteria (CLSI document M100-S20-U, 2010) were 98% and 83% for imipenem and 76% and 83% for meropenem, respectively. We propose an algorithm that is highly sensitive (98%) and specific (94%) for carbapenemase screening based on the combined use of imipenem and meropenem MICs.

摘要

对 104 株肠杆菌科细菌进行了亚胺培南和美罗培南 Vitek 2 MIC 值检测，以鉴定碳青霉烯酶产生菌。新 CLSI 解释标准（CLSI 文献 M100-S20-U，2010）对亚胺培南的敏感性和特异性值分别为 98%和 83%，对美罗培南的敏感性和特异性值分别为 76%和 83%。我们提出了一种基于联合使用亚胺培南和美罗培南 MIC 值的碳青霉烯酶筛选算法，该算法具有高敏感性（98%）和特异性（94%）。