School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, Cheshire CH64 7TE, UK.
Vet Rec. 2011 Dec 3;169(23):606. doi: 10.1136/vr.d4394. Epub 2011 Aug 31.
The present study is a randomised split-flock treatment trial, which compared the effect of foot bathing in a 1 per cent solution of chlortetracycline alone with a treatment protocol that added a single injection of a long-acting amoxicillin. Overall, the prevalence of contagious ovine digital dermatitis in the examined flock was 22 per cent, while 45.7 per cent of affected sheep had infections in two or more feet. Parenteral antibiotic treatment increased the odds of a recovery by 3.8 times (95 per cent confidence interval 1.05 to 14.0) (P=0.008). Moreover, the amoxicillin injection may also have had a preventative effect, reducing the rate of establishment of new infections from 2.5 per cent for foot bathing alone compared with 1.0 per cent with the addition of parenteral amoxicillin.
本研究为一项随机分组治疗试验，对比了单独使用 1%金霉素溶液足浴与添加长效阿莫西林单次注射的治疗方案的效果。总的来说，检查羊群中传染性绵羊数字皮炎的患病率为 22%，而 45.7%受感染的绵羊有两个或更多脚部感染。 全身用抗生素治疗使康复的可能性增加了 3.8 倍（95%置信区间 1.05 至 14.0）（P=0.008）。 此外，阿莫西林注射也可能具有预防作用，与单独使用金霉素溶液足浴相比，添加阿莫西林可将新感染的发生率从 2.5%降低至 1.0%。
