Department of Cardiothoracic and Vascular Sciences, Clinica Medica 2, University of Padua, Padua, Italy.
Blood. 2011 Oct 27;118(17):4719-22. doi: 10.1182/blood-2011-06-364232. Epub 2011 Aug 31.
Although it has been clearly demonstrated that venous thromboembolism is associated with an increased risk of subsequent overt cancer and arterial cardiovascular events in comparison with control populations, whether this association also applies to patients with isolated (ie, without concomitant involvement of the deep vein system) superficial vein thrombosis (SVT) in the legs is unknown. In 737 consecutive patients with isolated SVT not involving the sapheno-femoral junction, we conducted a retrospective investigation to assess the rate of cancer and that of arterial cardiovascular events occurring during follow-up. The event rates were compared with those occurring in 1438 controls having comparable characteristics. Both cases and controls were followed-up for an average period of 26 ± 8 months (range, 3-45). Malignancy was diagnosed in 26 cases (3.5%) and 56 controls (3.9%), leading to a hazard ratio of 0.86 (95% confidence interval, 0.55%-1.35%). Arterial cardiovascular events occurred in 32 cases (4.3%) and 63 controls (4.4%), leading to a hazard ratio of 0.97 (95% confidence interval, 0.63%-1.50%). We conclude that the occurrence of isolated SVT in the legs does not place patients at an increased risk of malignancies or arterial cardiovascular events. Whether this conclusion also applies to patients whose thrombosis involves the sapheno-femoral junction remains to be demonstrated.
虽然已经明确表明，与对照组相比，静脉血栓栓塞与随后明显的癌症和动脉心血管事件的风险增加相关，但这种关联是否也适用于孤立性（即无深静脉系统同时受累）下肢浅静脉血栓形成（SVT）的患者尚不清楚。在 737 例连续的孤立性不涉及股隐静脉交界的 SVT 患者中，我们进行了一项回顾性调查，以评估随访期间发生癌症和动脉心血管事件的发生率。将事件发生率与具有可比性特征的 1438 例对照者进行比较。病例和对照者的平均随访时间为 26 ± 8 个月（范围 3-45）。26 例（3.5%）和 56 例（3.9%）患者诊断为恶性肿瘤，导致危险比为 0.86（95%置信区间，0.55%-1.35%）。32 例（4.3%）和 63 例（4.4%）患者发生动脉心血管事件，导致危险比为 0.97（95%置信区间，0.63%-1.50%）。我们的结论是，孤立性下肢 SVT 的发生并不会使患者面临恶性肿瘤或动脉心血管事件的风险增加。这种结论是否也适用于血栓形成累及股隐静脉交界的患者仍有待证明。
