University Hospital, Saint-Etienne, France.
Ann Intern Med. 2010 Feb 16;152(4):218-24. doi: 10.7326/0003-4819-152-4-201002160-00006.
Superficial venous thrombosis (SVT) is perceived to have a benign prognosis.
To assess the prevalence of venous thromboembolism in patients with SVT and to determine the 3-month incidence of thromboembolic complications.
National cross-sectional and prospective epidemiologic cohort study. (ClinicalTrials.gov registration number: NCT00818688)
French office- and hospital-based vascular medicine specialists.
844 consecutive patients with symptomatic SVT of the lower limbs that was at least 5 cm on compression ultrasonography.
Incidence of venous thromboembolism and extension or recurrence of SVT in patients with isolated SVT at presentation.
Among 844 patients with SVT at inclusion (median age, 65 years; 547 women), 210 (24.9%) also had deep venous thrombosis (DVT) or symptomatic pulmonary embolism. Among 600 patients without DVT or pulmonary embolism at inclusion who were eligible for 3-month follow-up, 58 (10.2%) developed thromboembolic complications at 3 months (pulmonary embolism, 3 [0.5%]; DVT, 15 [2.8%]; extension of SVT, 18 [3.3%]; and recurrence of SVT, 10 [1.9%]), despite 540 patients (90.5%) having received anticoagulants. Risk factors for complications at 3 months were male sex, history of DVT or pulmonary embolism, previous cancer, and absence of varicose veins.
The findings are from a specialist referral setting, and the study was terminated before the target patient population was reached because of slow recruitment.
A substantial number of patients with SVT exhibit venous thromboembolism at presentation, and some that do not can develop this complication in the subsequent 3 months.
GlaxoSmithKline, sanofi-aventis, and the Ministère Francais de la Santé et des Sports (Programme Hospitalier de Recherche Clinique).
浅静脉血栓（SVT）被认为预后良好。
评估有症状的下肢 SVT 患者中静脉血栓栓塞症的发生率，并确定血栓栓塞并发症的 3 个月发生率。
全国性的横断面和前瞻性的流行病学队列研究。（临床试验.gov 注册号：NCT00818688）
法国的办公室和医院血管医学专家。
844 例连续出现症状性下肢 SVT 的患者，这些患者的 SVT 在加压超声检查时至少为 5cm。
在最初表现为孤立性 SVT 的患者中，静脉血栓栓塞症的发生率以及 SVT 的扩展或复发。
在纳入的 844 例 SVT 患者中（中位年龄 65 岁；547 例女性），210 例（24.9%）还患有深静脉血栓形成（DVT）或有症状的肺栓塞。在纳入的 600 例无 DVT 或肺栓塞且有资格进行 3 个月随访的患者中，58 例（10.2%）在 3 个月时发生血栓栓塞并发症（肺栓塞 3 例[0.5%]；DVT 15 例[2.8%]；SVT 扩展 18 例[3.3%]；SVT 复发 10 例[1.9%]），尽管有 540 例（90.5%）患者接受了抗凝治疗。3 个月时发生并发症的危险因素为男性、DVT 或肺栓塞史、既往癌症和无静脉曲张。
研究结果来自专家转诊环境，由于招募缓慢，研究在达到目标患者人群之前提前终止。
相当数量的 SVT 患者在初次就诊时即存在静脉血栓栓塞症，而一些没有这种情况的患者在随后的 3 个月内可能会发生这种并发症。
葛兰素史克、赛诺菲-安万特和法国卫生部和体育部（临床研究医院计划）。
