Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Blood. 2011 Oct 27;118(17):4663-5. doi: 10.1182/blood-2011-06-362392. Epub 2011 Aug 31.
The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given variable platelet release of VEGF. We therefore compared plasma levels of VEGF in 29 patients with POEMS syndrome with those of other disorders (n = 76). We demonstrated that plasma VEGF levels are useful in differentiating POEMS from other plasma cell dyscrasias, neuropathic processes, and multisystem illnesses. Plasma VEGF is also useful in monitoring disease activity after treatment and correlates with clinical improvements better than hematologic response.
POEMS 综合征与血管内皮生长因子（VEGF）水平升高有关。多项研究比较了 POEMS 患者与其他疾病实体的血清 VEGF 水平，结果显示 POEMS 综合征患者的血清 VEGF 水平更高；然而，由于 VEGF 可变的血小板释放，尚不清楚血清水平是否可靠且可重现。因此，我们比较了 29 例 POEMS 综合征患者和其他疾病（n=76）的血浆 VEGF 水平。我们证明，血浆 VEGF 水平有助于区分 POEMS 与其他浆细胞异常、神经病性过程和多系统疾病。血浆 VEGF 也可用于监测治疗后的疾病活动，并与临床改善的相关性优于血液学反应。
