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阻断白细胞介素 6/糖蛋白 130 信号转导的治疗策略。

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.

机构信息

Department of Infection, Immunity and Biochemistry, The School of Medicine, Cardiff University, Cardiff, United Kingdom.

出版信息

J Clin Invest. 2011 Sep;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.

DOI:10.1172/JCI57158
PMID:21881215
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3163962/
Abstract

The successful treatment of certain autoimmune conditions with the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.

摘要

某些自身免疫性疾病经人源化抗白细胞介素 6 受体（IL-6R）抗体托珠单抗成功治疗后，凸显了通过β 受体亚基糖蛋白 130（gp130）信号传导的细胞因子的临床重要性。在这篇综述中，我们探讨了 gp130 信号如何控制疾病进展，并研究了为什么 IL-6 在这些细胞因子中作为炎症调节剂具有特殊作用。我们将关注可溶性 IL-6R 的作用，并提供自身免疫、炎症和癌症中 IL-6 活性的临床阻断的视角。

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本文引用的文献

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Trends Immunol. 2011 Aug;32(8):380-7. doi: 10.1016/j.it.2011.05.005. Epub 2011 Jul 13.
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Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.在溃疡性结肠炎的小鼠模型中，肿瘤的发展依赖于结肠 F4/80+CD11b（高）Gr1（低）巨噬细胞的 MyD88 信号转导。
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Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.白细胞介素 6 转染信号通过 Stat3/Socs3 的激活促进胰腺上皮内瘤变的进展和胰腺癌的发生。
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In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment.抗白细胞介素-6受体抑制剂托珠单抗对B细胞区室的体内作用。
Arthritis Rheum. 2011 May;63(5):1255-64. doi: 10.1002/art.30242.
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