阻断白细胞介素 6/糖蛋白 130 信号转导的治疗策略。
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.
机构信息
Department of Infection, Immunity and Biochemistry, The School of Medicine, Cardiff University, Cardiff, United Kingdom.
出版信息
J Clin Invest. 2011 Sep;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
Abstract
The successful treatment of certain autoimmune conditions with the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.
摘要
某些自身免疫性疾病经人源化抗白细胞介素 6 受体（IL-6R）抗体托珠单抗成功治疗后，凸显了通过β 受体亚基糖蛋白 130（gp130）信号传导的细胞因子的临床重要性。在这篇综述中，我们探讨了 gp130 信号如何控制疾病进展，并研究了为什么 IL-6 在这些细胞因子中作为炎症调节剂具有特殊作用。我们将关注可溶性 IL-6R 的作用，并提供自身免疫、炎症和癌症中 IL-6 活性的临床阻断的视角。
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