miR-10 微 RNA 前体家族。
The miR-10 microRNA precursor family.
机构信息
Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
出版信息
RNA Biol. 2011 Sep-Oct;8(5):728-34. doi: 10.4161/rna.8.5.16324. Epub 2011 Sep 1.
Abstract
The miR-10 microRNA precursor family encodes a group of short non-coding RNAs involved in gene regulation. The miR-10 family is highly conserved and has sparked the interest of many research groups because of the genomic localization in the vicinity of, coexpression with and regulation of the Hox gene developmental regulators. Here, we review the current knowledge of the evolution, physiological function and involvement in cancer of this family of microRNAs.
摘要
miR-10 微 RNA 前体家族编码一组参与基因调控的短非编码 RNA。miR-10 家族高度保守，其在基因组中的定位邻近、与 Hox 基因发育调控因子共表达以及对其的调控作用引起了许多研究小组的兴趣。本文综述了该微 RNA 家族的进化、生理功能及其在癌症中的作用的现有知识。
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