Vascular Biology and Atherosclerosis Laboratory, Baker IDI Heart and Diabetes Institute, Department of Medicine, Centre for Inflammatory Diseases, Faculty of Medicine, Southern Clinical School, Nursing and Health Sciences, Monash University, Victoria, Australia.
Curr Opin Lipidol. 2011 Oct;22(5):373-9. doi: 10.1097/MOL.0b013e32834adaf3.
Inflammation, in addition to high cholesterol is a major factor contributing to atherosclerosis-associated adverse cardiovascular events. Thus, there is a pressing need for additional therapeutic strategies to reduce inflammation, by targeting immune cells and cytokines. Here we review B cell subsets and adventitial and intimal B cells in atherosclerosis development and discuss potential B cell-targeted anti-inflammatory therapies for atherosclerosis.
B cell subsets can have opposing proatherogenic and atheroprotective roles in atherosclerosis. CD-20-targeted B cell depletion has been shown to decrease murine atherosclerotic lesions. The accumulation of intimal and adventitial B cells associated with atherosclerotic lesions is consistent with their participation in local inflammatory responses. As B2 B cells are proatherogenic, blocking its survival factor B cell activating factor may selectively delete this proatherogenic subset.
Both intimal and adventitial B cells appear important in atherosclerosis. B2 B cells are proatherogenic and other subsets such as regulatory B cells are antiatherogenic. Future B cell-targeted therapy for atherosclerosis should be customized to selectively deplete damaging B2 B cells while sparing or expanding protective B cell subsets.
除了高胆固醇外，炎症也是导致动脉粥样硬化相关不良心血管事件的主要因素。因此，迫切需要通过靶向免疫细胞和细胞因子来寻找额外的治疗策略来减少炎症。本文回顾了 B 细胞亚群以及动脉粥样硬化发展中的外膜和内膜 B 细胞，并讨论了潜在的针对动脉粥样硬化的 B 细胞靶向抗炎治疗。
B 细胞亚群在动脉粥样硬化中可能具有相反的促动脉粥样硬化和动脉保护作用。CD-20 靶向 B 细胞耗竭已被证明可减少小鼠动脉粥样硬化病变。与动脉粥样硬化病变相关的内膜和外膜 B 细胞的积累与其参与局部炎症反应一致。由于 B2 B 细胞具有促动脉粥样硬化作用，阻断其生存因子 B 细胞激活因子可能会选择性地删除这种促动脉粥样硬化亚群。
内膜和外膜 B 细胞似乎在动脉粥样硬化中都很重要。B2 B 细胞具有促动脉粥样硬化作用，而其他亚群如调节性 B 细胞则具有抗动脉粥样硬化作用。未来针对动脉粥样硬化的 B 细胞靶向治疗应该进行定制，以选择性地耗尽有害的 B2 B 细胞，同时保留或扩展保护性 B 细胞亚群。
