Department of Physiology and Biophysics, Institute of Biomedical Sciences, São Paulo University, São Paulo, Brazil.
J Invest Dermatol. 2012 Jan;132(1):208-15. doi: 10.1038/jid.2011.265. Epub 2011 Sep 1.
The effects of oral ingestion of oleic (OLA) and linoleic (LNA) acids on wound healing in rats were investigated. LNA increased the influx of inflammatory cells, the concentration of hydrogen peroxide (H(2)O(2)) and cytokine-induced neutrophil chemoattractant-2αβ (CINC-2αβ), and the activation of the transcription factor activator protein-1 (AP-1) in the wound at 1 hour post wounding. LNA decreased the number of inflammatory cells and IL-1, IL-6, and macrophage inflammatory protein-3 (MIP-3) concentrations, as well as NF-κB activation in the wound at 24 hours post wounding. LNA accelerated wound closure over a period of 7 days. OLA increased TNF-α concentration and NF-κB activation at 1 hour post wounding. A reduction of IL-1, IL-6, and MIP-3α concentrations, as well as NF-κB activation, was observed 24 hours post wounding in the OLA group. These data suggest that OLA and LNA accelerate the inflammatory phase of wound healing, but that they achieve this through different mechanisms.
研究了油酸（OLA）和亚油酸（LNA）口服对大鼠伤口愈合的影响。LNA 在创伤后 1 小时增加炎症细胞的流入、过氧化氢（H₂O₂）的浓度和细胞因子诱导的中性粒细胞趋化因子-2αβ（CINC-2αβ），并激活转录因子激活蛋白-1（AP-1）。LNA 在创伤后 24 小时减少炎症细胞的数量和 IL-1、IL-6 和巨噬细胞炎症蛋白-3（MIP-3）的浓度，以及 NF-κB 的激活。LNA 在 7 天的时间内加速了伤口的闭合。OLA 在创伤后 1 小时增加 TNF-α浓度和 NF-κB 的激活。在 OLA 组中，观察到 IL-1、IL-6 和 MIP-3α浓度以及 NF-κB 激活的减少在创伤后 24 小时。这些数据表明，OLA 和 LNA 加速伤口愈合的炎症期，但它们通过不同的机制实现这一点。
