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Testing time for telomeres. Telomere length can tell us something about disease susceptibility and ageing, but are commercial tests ready for prime time?端粒的检测时机。端粒长度能让我们了解一些关于疾病易感性和衰老的信息,但商业检测准备好进入黄金时期了吗?
EMBO Rep. 2011 Sep 1;12(9):897-900. doi: 10.1038/embor.2011.166.
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Hypothesis on transmission of longevity based on telomere length and state of integrity.基于端粒长度和完整性状态的长寿传递假说。
Med Hypotheses. 2004;62(5):770-2. doi: 10.1016/j.mehy.2003.12.017.
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Cell biology. Are telomere tests ready for prime time?细胞生物学。端粒检测准备好进入黄金时代了吗?
Science. 2011 Apr 22;332(6028):414-5. doi: 10.1126/science.332.6028.414.
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Telomeres, Nutrition, and Longevity: Can We Really Navigate Our Aging?端粒、营养与长寿:我们真的能掌控衰老吗?
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The epidemiology of human telomeres: faults and promises.人类端粒的流行病学:缺陷与前景。
J Gerontol A Biol Sci Med Sci. 2008 Sep;63(9):979-83. doi: 10.1093/gerona/63.9.979.
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Leukocytes of exceptionally old persons display ultra-short telomeres.高龄老人的白细胞表现出超短的端粒。
Am J Physiol Regul Integr Comp Physiol. 2007 Dec;293(6):R2210-7. doi: 10.1152/ajpregu.00615.2007. Epub 2007 Sep 26.
7
Telomere attrition as ageing biomarker.端粒损耗作为衰老生物标志物。
Anticancer Res. 2005 Jul-Aug;25(4):3011-21.
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Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica.在寿命最长的非群居动物北极露脊鲸中,端粒独立的衰老。
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Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird.在基因组中,就一种长寿海鸟的适应性组成部分而言,长端粒比短端粒更具信息价值。
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A synopsis on aging-Theories, mechanisms and future prospects.衰老综述——理论、机制与未来展望
Ageing Res Rev. 2016 Aug;29:90-112. doi: 10.1016/j.arr.2016.06.005. Epub 2016 Jun 25.
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Optimization of a Relative Telomere Length Assay by Monochromatic Multiplex Real-Time Quantitative PCR on the LightCycler 480: Sources of Variability and Quality Control Considerations.基于LightCycler 480的单色多重实时定量PCR对相对端粒长度检测方法的优化:变异来源及质量控制考量
J Mol Diagn. 2016 May;18(3):425-437. doi: 10.1016/j.jmoldx.2016.01.004. Epub 2016 Mar 8.
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Childhood exposure to violence and lifelong health: clinical intervention science and stress-biology research join forces.儿童期暴力暴露与终生健康:临床干预科学与应激生物学研究携手合作。
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Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study.儿童期遭受暴力与 5 至 10 岁时端粒侵蚀有关:一项纵向研究。
Mol Psychiatry. 2013 May;18(5):576-81. doi: 10.1038/mp.2012.32. Epub 2012 Apr 24.

本文引用的文献

1
The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence.端粒酶激活剂 TA-65 可延长短端粒,增加成年/老年小鼠的健康寿命,而不增加癌症发病率。
Aging Cell. 2011 Aug;10(4):604-21. doi: 10.1111/j.1474-9726.2011.00700.x. Epub 2011 Apr 14.
2
A natural product telomerase activator as part of a health maintenance program.天然产物端粒酶激活剂作为健康维护计划的一部分。
Rejuvenation Res. 2011 Feb;14(1):45-56. doi: 10.1089/rej.2010.1085. Epub 2010 Sep 7.
3
Telomere length and risk of incident cancer and cancer mortality.端粒长度与癌症发病风险和癌症死亡率。
JAMA. 2010 Jul 7;304(1):69-75. doi: 10.1001/jama.2010.897.
4
Cloning yeast telomeres on linear plasmid vectors.在线性质粒载体上克隆酵母端粒
Cell. 1982 May;29(1):245-55. doi: 10.1016/0092-8674(82)90109-x.
5
A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.一种边缘切开术理论。多核苷酸酶促合成中模板边缘的不完全复制及该现象的生物学意义。
J Theor Biol. 1973 Sep 14;41(1):181-90. doi: 10.1016/0022-5193(73)90198-7.
6
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena.四膜虫染色体外核糖体RNA基因末端的串联重复序列。
J Mol Biol. 1978 Mar 25;120(1):33-53. doi: 10.1016/0022-2836(78)90294-2.

Testing time for telomeres. Telomere length can tell us something about disease susceptibility and ageing, but are commercial tests ready for prime time?

作者信息

Wolinsky Howard

出版信息

EMBO Rep. 2011 Sep 1;12(9):897-900. doi: 10.1038/embor.2011.166.

DOI:10.1038/embor.2011.166
PMID:21881613
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3166469/
Abstract
摘要